1t2r
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 1t2r |SIZE=350|CAPTION= <scene name='initialview01'>1t2r</scene> | |PDB= 1t2r |SIZE=350|CAPTION= <scene name='initialview01'>1t2r</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=A:ADENOSINE-5'-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5'-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=U:URIDINE-5'-MONOPHOSPHATE'>U</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1t2s|1T2S]], [[1upo|1UPO]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t2r OCA], [http://www.ebi.ac.uk/pdbsum/1t2r PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1t2r RCSB]</span> | ||
}} | }} | ||
| Line 29: | Line 32: | ||
[[Category: rna]] | [[Category: rna]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:50:25 2008'' |
Revision as of 20:50, 30 March 2008
| |||||||
| Ligands: | , , | ||||||
| Related: | 1T2S, 1UPO
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain
Overview
We describe the solution structures of the Argonaute2 PAZ domain bound to RNA and DNA oligonucleotides. The structures reveal a unique mode of single-stranded nucleic acid binding in which the two 3'-terminal nucleotides are buried in a hydrophobic cleft. We propose that the PAZ domain contributes to the specific recognition of siRNAs by providing a binding pocket for their characteristic two-nucleotide 3' overhangs.
About this Structure
1T2R is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.
Reference
Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain., Lingel A, Simon B, Izaurralde E, Sattler M, Nat Struct Mol Biol. 2004 Jun;11(6):576-7. Epub 2004 May 23. PMID:15156196
Page seeded by OCA on Sun Mar 30 23:50:25 2008
