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1wxn
From Proteopedia
(Difference between revisions)
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wxn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wxn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wxn RCSB], [http://www.ebi.ac.uk/pdbsum/1wxn PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wxn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wxn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wxn RCSB], [http://www.ebi.ac.uk/pdbsum/1wxn PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/APT2_ANTEL APT2_ANTEL]] Potently and selectively blocks the acid-sensing ion channel ASIC3 (ACCN3). The blockade is rapid and reversible. Also inhibits heteromeric ASIC2b-ASIC3 (ACCN1-ACCN3) channel, while it has less affinity for ASIC1b-ASIC3 (ACCN2-ACCN3), ASIC1a-ASIC3 (ACCN2-ASIC3).<ref>PMID:15044953</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 19:57, 24 December 2014
Solution structure of APETx2, a specific peptide inhibitor of ASIC3 proton-gated channels
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