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1tbx

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|PDB= 1tbx |SIZE=350|CAPTION= <scene name='initialview01'>1tbx</scene>, resolution 2.70&Aring;
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tbx OCA], [http://www.ebi.ac.uk/pdbsum/1tbx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tbx RCSB]</span>
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[[Category: winged helix]]
[[Category: winged helix]]
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Revision as of 20:54, 30 March 2008

Image:1tbx.jpg


PDB ID 1tbx

Drag the structure with the mouse to rotate
, resolution 2.70Å
Ligands:
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Crystal structure of SSV1 F-93


Overview

Sulfolobus spindle-shaped viruses (SSVs), or Fuselloviridae, are ubiquitous crenarchaeal viruses found in high-temperature acidic hot springs around the world (pH </=4.0; temperature of >/=70 degrees C). Because they are relatively easy to isolate, they represent the best studied of the crenarchaeal viruses. This is particularly true for the type virus, SSV1, which contains a double-stranded DNA genome of 15.5 kilobases, encoding 34 putative open reading frames. Interestingly, the genome shows little sequence similarity to organisms other than its SSV homologues. Together, sequence similarity and biochemical analyses have suggested functions for only 6 of the 34 open reading frames. Thus, even though SSV1 is the best-studied crenarchaeal virus, functions for most (28) of its open reading frames remain unknown. We have undertaken biochemical and structural studies for the gene product of open reading frame F-93. We find that F-93 exists as a homodimer in solution and that a tight dimer is also present in the 2.7-A crystal structure. Further, the crystal structure reveals a fold that is homologous to the SlyA and MarR subfamilies of winged-helix DNA binding proteins. This strongly suggests that F-93 functions as a transcription factor that recognizes a (pseudo-)palindromic DNA target sequence.

About this Structure

1TBX is a Single protein structure of sequence from Sulfolobus virus 1. Full crystallographic information is available from OCA.

Reference

Crystal structure of F-93 from Sulfolobus spindle-shaped virus 1, a winged-helix DNA binding protein., Kraft P, Oeckinghaus A, Kummel D, Gauss GH, Gilmore J, Wiedenheft B, Young M, Lawrence CM, J Virol. 2004 Nov;78(21):11544-50. PMID:15479795

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