1tgh
From Proteopedia
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|PDB= 1tgh |SIZE=350|CAPTION= <scene name='initialview01'>1tgh</scene>, resolution 2.900Å | |PDB= 1tgh |SIZE=350|CAPTION= <scene name='initialview01'>1tgh</scene>, resolution 2.900Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=DA:2'-DEOXYADENOSINE-5'-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5'-MONOPHOSPHATE'>DT</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= TBP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= TBP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tgh OCA], [http://www.ebi.ac.uk/pdbsum/1tgh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tgh RCSB]</span> | ||
}} | }} | ||
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==Disease== | ==Disease== | ||
| - | Known | + | Known disease associated with this structure: Huntington disease-like-4 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600075 600075]], Parkinson disease OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600075 600075]], Spinocerebellar ataxia 17 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600075 600075]] |
==About this Structure== | ==About this Structure== | ||
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[[Category: transcription factor]] | [[Category: transcription factor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:55:43 2008'' |
Revision as of 20:55, 30 March 2008
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| , resolution 2.900Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , | ||||||
| Gene: | TBP (Homo sapiens) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
TATA BINDING PROTEIN (TBP)/DNA COMPLEX
Contents |
Overview
The crystal structure of a complex of human TATA-binding protein with TATA-sequence DNA has been solved, complementing earlier TBP/DNA analyses from Saccharomyces cerevisiae and Arabidopsis thaliana. Special insight into TATA box specificity is provided by considering the TBP/DNA complex, not as a protein molecule with bound DNA, but as a DNA duplex with a particularly large minor groove ligand. This point of view provides explanations for: (1) why T.A base-pairs are required rather than C.G; (2) why an alternation of T and A bases is needed; (3) how TBP recognizes the upstream and downstream ends of the TATA box in order to bind properly; and (4) why the second half of the TATA box can be more variable than the first.
Disease
Known disease associated with this structure: Huntington disease-like-4 OMIM:[600075], Parkinson disease OMIM:[600075], Spinocerebellar ataxia 17 OMIM:[600075]
About this Structure
1TGH is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1TGH with [TATA-Binding Protein]. Full crystallographic information is available from OCA.
Reference
How proteins recognize the TATA box., Juo ZS, Chiu TK, Leiberman PM, Baikalov I, Berk AJ, Dickerson RE, J Mol Biol. 1996 Aug 16;261(2):239-54. PMID:8757291
Page seeded by OCA on Sun Mar 30 23:55:43 2008
