1thj
From Proteopedia
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|PDB= 1thj |SIZE=350|CAPTION= <scene name='initialview01'>1thj</scene>, resolution 2.8Å | |PDB= 1thj |SIZE=350|CAPTION= <scene name='initialview01'>1thj</scene>, resolution 2.8Å | ||
|SITE= <scene name='pdbsite=1:Active+Site+1,+Located+Between+A+And+C+Chain'>1</scene>, <scene name='pdbsite=2:Active+Site+2,+Located+Between+B+And+A+Chain'>2</scene> and <scene name='pdbsite=3:Active+Site+3,+Located+Between+C+And+B+Chain'>3</scene> | |SITE= <scene name='pdbsite=1:Active+Site+1,+Located+Between+A+And+C+Chain'>1</scene>, <scene name='pdbsite=2:Active+Site+2,+Located+Between+B+And+A+Chain'>2</scene> and <scene name='pdbsite=3:Active+Site+3,+Located+Between+C+And+B+Chain'>3</scene> | ||
| - | |LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene> | + | |LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1thj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1thj OCA], [http://www.ebi.ac.uk/pdbsum/1thj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1thj RCSB]</span> | ||
}} | }} | ||
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[[Category: Rees, D C.]] | [[Category: Rees, D C.]] | ||
[[Category: Schindelin, H.]] | [[Category: Schindelin, H.]] | ||
| - | [[Category: ZN]] | ||
[[Category: carbonic anhydrase]] | [[Category: carbonic anhydrase]] | ||
[[Category: lyase (oxo-acid)]] | [[Category: lyase (oxo-acid)]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:56:06 2008'' |
Revision as of 20:56, 30 March 2008
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| , resolution 2.8Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | , and | ||||||
| Ligands: | |||||||
| Activity: | Carbonate dehydratase, with EC number 4.2.1.1 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CARBONIC ANHYDRASE FROM METHANOSARCINA
Overview
A carbonic anhydrase from the thermophilic archaeon Methanosarcina thermophila that exhibits no significant sequence similarity to known carbonic anhydrases has recently been characterized. Here we present the structure of this enzyme, which adopts a left-handed parallel beta-helix fold. This fold is of particular interest since it contains only left-handed crossover connections between the parallel beta-strands, which so far have been observed very infrequently. The active form of the enzyme is a trimer with three zinc-containing active sites, each located at the interface between two monomers. While the arrangement of active site groups differs between this enzyme and the carbonic anhydrases from higher vertebrates, there are structural similarities in the zinc coordination environment, suggestive of convergent evolution dictated by the chemical requirements for catalysis of the same reaction. Based on sequence similarities, the structure of this enzyme is the prototype of a new class of carbonic anhydrases with representatives in all three phylogenetic domains of life.
About this Structure
1THJ is a Single protein structure of sequence from Methanosarcina thermophila. The following page contains interesting information on the relation of 1THJ with [Carbonic Anhydrase]. Full crystallographic information is available from OCA.
Reference
A left-hand beta-helix revealed by the crystal structure of a carbonic anhydrase from the archaeon Methanosarcina thermophila., Kisker C, Schindelin H, Alber BE, Ferry JG, Rees DC, EMBO J. 1996 May 15;15(10):2323-30. PMID:8665839
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