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1tip

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|PDB= 1tip |SIZE=350|CAPTION= <scene name='initialview01'>1tip</scene>, resolution 2.2&Aring;
|PDB= 1tip |SIZE=350|CAPTION= <scene name='initialview01'>1tip</scene>, resolution 2.2&Aring;
|SITE=
|SITE=
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|LIGAND= <scene name='pdbligand=F6P:FRUCTOSE-6-PHOSPHATE'>F6P</scene>
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|LIGAND= <scene name='pdbligand=F6P:FRUCTOSE-6-PHOSPHATE'>F6P</scene>, <scene name='pdbligand=NEP:N1-PHOSPHONOHISTIDINE'>NEP</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Fructose-2,6-bisphosphate_2-phosphatase Fructose-2,6-bisphosphate 2-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.46 3.1.3.46]
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-2,6-bisphosphate_2-phosphatase Fructose-2,6-bisphosphate 2-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.46 3.1.3.46] </span>
|GENE= A CODING REGION WHICH COVERS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
|GENE= A CODING REGION WHICH COVERS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
 +
|DOMAIN=
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tip OCA], [http://www.ebi.ac.uk/pdbsum/1tip PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tip RCSB]</span>
}}
}}
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[[Category: Ogata, C M.]]
[[Category: Ogata, C M.]]
[[Category: Olson, T W.]]
[[Category: Olson, T W.]]
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[[Category: F6P]]
 
[[Category: alternative splicing]]
[[Category: alternative splicing]]
[[Category: atp-binding]]
[[Category: atp-binding]]
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[[Category: transferase]]
[[Category: transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:18:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:56:35 2008''

Revision as of 20:56, 30 March 2008

Image:1tip.jpg


PDB ID 1tip

Drag the structure with the mouse to rotate
, resolution 2.2Å
Ligands: ,
Gene: A CODING REGION WHICH COVERS (Rattus norvegicus)
Activity: Fructose-2,6-bisphosphate 2-phosphatase, with EC number 3.1.3.46
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



THE BISPHOSPHATASE DOMAIN OF THE BIFUNCTIONAL RAT LIVER 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE


Overview

The crystal structure of the fructose-2,6-bisphosphatase domain trapped during the reaction reveal a phosphorylated His 258, and a water molecule immobilized by the product, fructose-6-phosphate. The geometry suggests that the dephosphorylation step requires prior removal of the product for an 'associative in-line' phosphoryl transfer to the catalytic water.

About this Structure

1TIP is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a trapped phosphoenzyme during a catalytic reaction., Lee YH, Olson TW, Ogata CM, Levitt DG, Banaszak LJ, Lange AJ, Nat Struct Biol. 1997 Aug;4(8):615-8. PMID:9253407

Page seeded by OCA on Sun Mar 30 23:56:35 2008

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