1tm6
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 1tm6 |SIZE=350|CAPTION= <scene name='initialview01'>1tm6</scene> | |PDB= 1tm6 |SIZE=350|CAPTION= <scene name='initialview01'>1tm6</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene> | + | |LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tm6 OCA], [http://www.ebi.ac.uk/pdbsum/1tm6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tm6 RCSB]</span> | ||
}} | }} | ||
| Line 24: | Line 27: | ||
[[Category: Alexandrescu, A T.]] | [[Category: Alexandrescu, A T.]] | ||
[[Category: Matousek, W M.]] | [[Category: Matousek, W M.]] | ||
| - | [[Category: ZN]] | ||
[[Category: beta hairpin]] | [[Category: beta hairpin]] | ||
[[Category: seca]] | [[Category: seca]] | ||
[[Category: zinc finger]] | [[Category: zinc finger]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:58:02 2008'' |
Revision as of 20:58, 30 March 2008
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| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
NMR Structure of the Free Zinc Binding C-terminal Domain of SecA
Overview
SecA is an integral component of the prokaryotic Sec preprotein secretory translocase system. We report here the solution NMR structure of a fragment corresponding to the C-terminal domain of Escherichia coli SecA. In the presence of Zn2+, the fragment adopts a shortened version of the classic betabetaalpha zinc finger fold. The isolated C-terminal domain shows substantial differences from the X-ray structure of a homologous SecA domain bound to the chaperone-like cofactor SecB. The differences between the structures of the free and bound forms suggest that binding to SecB causes a perturbation of the C-terminal domain's intrinsically favored betabetaalpha fold.
About this Structure
1TM6 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
NMR structure of the C-terminal domain of SecA in the free state., Matousek WM, Alexandrescu AT, Biochim Biophys Acta. 2004 Nov 1;1702(2):163-71. PMID:15488768
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