1tnq
From Proteopedia
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|PDB= 1tnq |SIZE=350|CAPTION= <scene name='initialview01'>1tnq</scene> | |PDB= 1tnq |SIZE=350|CAPTION= <scene name='initialview01'>1tnq</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene> | + | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= NTNC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus]) | |GENE= NTNC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tnq OCA], [http://www.ebi.ac.uk/pdbsum/1tnq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tnq RCSB]</span> | ||
}} | }} | ||
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[[Category: Gagne, S M.]] | [[Category: Gagne, S M.]] | ||
[[Category: Sykes, B D.]] | [[Category: Sykes, B D.]] | ||
| - | [[Category: CA]] | ||
[[Category: ef-hand]] | [[Category: ef-hand]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:58:40 2008'' |
Revision as of 20:58, 30 March 2008
| |||||||
| Ligands: | |||||||
| Gene: | NTNC (Gallus gallus) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURES OF THE APO AND CALCIUM TROPONIN-C REGULATORY DOMAINS: THE MUSCLE CONTRACTION SWITCH
Overview
Regulation of contraction in skeletal muscle occurs through calcium binding to the protein troponin C. The solution structures of the regulatory domain of apo and calcium-loaded troponin C have been determined by multinuclear, multidimensional nuclear magnetic resonance techniques. The structural transition in the regulatory domain of troponin C on calcium binding involves an opening of the structure through large changes in interhelical angles. This leads to the increased exposure of an extensive hydrophobic patch, an event that triggers skeletal muscle contraction.
About this Structure
1TNQ is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.
Reference
Structures of the troponin C regulatory domains in the apo and calcium-saturated states., Gagne SM, Tsuda S, Li MX, Smillie LB, Sykes BD, Nat Struct Biol. 1995 Sep;2(9):784-9. PMID:7552750
Page seeded by OCA on Sun Mar 30 23:58:40 2008
