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1tow
From Proteopedia
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|PDB= 1tow |SIZE=350|CAPTION= <scene name='initialview01'>1tow</scene>, resolution 2.00Å | |PDB= 1tow |SIZE=350|CAPTION= <scene name='initialview01'>1tow</scene>, resolution 2.00Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=CRZ:4-(9H-CARBAZOL-9-YL)BUTANOIC ACID'>CRZ</scene> | + | |LIGAND= <scene name='pdbligand=CRZ:4-(9H-CARBAZOL-9-YL)BUTANOIC+ACID'>CRZ</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1tou|1TOU]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tow OCA], [http://www.ebi.ac.uk/pdbsum/1tow PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tow RCSB]</span> | ||
}} | }} | ||
| Line 31: | Line 34: | ||
[[Category: Svensson, S.]] | [[Category: Svensson, S.]] | ||
[[Category: Uppenberg, J.]] | [[Category: Uppenberg, J.]] | ||
| - | [[Category: CRZ]] | ||
[[Category: lipid-binding]] | [[Category: lipid-binding]] | ||
[[Category: transport]] | [[Category: transport]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:59:05 2008'' |
Revision as of 20:59, 30 March 2008
| |||||||
| , resolution 2.00Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Related: | 1TOU
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of human adipocyte fatty acid binding protein in complex with a carboxylic acid ligand
Overview
Low micromolar human A-FABP inhibitors were found by utilizing a fluorescence polarization assay, X-ray crystallography and modeling. The carbazole- and indole-based inhibitors displayed approximately 10-fold preferences over human H-FABP and E-FABP, and are highly selective against I-FABP. This communication describes the SAR for drug-like synthetic inhibitors of human A-FABP.
About this Structure
1TOW is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target., Lehmann F, Haile S, Axen E, Medina C, Uppenberg J, Svensson S, Lundback T, Rondahl L, Barf T, Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8. PMID:15357969
Page seeded by OCA on Sun Mar 30 23:59:05 2008
Categories: Homo sapiens | Single protein | Axen, E. | Barf, T. | Haile, S. | Lehmann, F. | Lundback, T. | Medina, C. | Rondahl, L. | Svensson, S. | Uppenberg, J. | Lipid-binding | Transport
