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1by1
From Proteopedia
(Difference between revisions)
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1by1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1by1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1by1 RCSB], [http://www.ebi.ac.uk/pdbsum/1by1 PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1by1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1by1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1by1 RCSB], [http://www.ebi.ac.uk/pdbsum/1by1 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ARHG7_HUMAN ARHG7_HUMAN]] Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.<ref>PMID:19041750</ref> <ref>PMID:18716323</ref> <ref>PMID:18184567</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 22:42, 24 December 2014
DBL homology domain from beta-PIX
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