1bfe
From Proteopedia
(Difference between revisions)
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bfe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bfe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bfe RCSB], [http://www.ebi.ac.uk/pdbsum/1bfe PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bfe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bfe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bfe RCSB], [http://www.ebi.ac.uk/pdbsum/1bfe PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 03:17, 25 December 2014
THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95
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