1txy

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|PDB= 1txy |SIZE=350|CAPTION= <scene name='initialview01'>1txy</scene>, resolution 2.00&Aring;
|PDB= 1txy |SIZE=350|CAPTION= <scene name='initialview01'>1txy</scene>, resolution 2.00&Aring;
|SITE=
|SITE=
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|LIGAND=
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
|ACTIVITY=
|ACTIVITY=
|GENE= PRIB, B4201 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
|GENE= PRIB, B4201 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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|DOMAIN=
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1txy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1txy OCA], [http://www.ebi.ac.uk/pdbsum/1txy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1txy RCSB]</span>
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}}
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[[Category: ob fold]]
[[Category: ob fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:24:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:02:36 2008''

Revision as of 21:02, 30 March 2008


PDB ID 1txy

Drag the structure with the mouse to rotate
, resolution 2.00Å
Ligands:
Gene: PRIB, B4201 (Escherichia coli)
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



E. coli PriB


Overview

Maintenance of genome stability following DNA damage requires origin-independent reinitiation of DNA replication at repaired replication forks. In E. coli, PriA, PriB, PriC, and DnaT play critical roles in recognizing repaired replication forks and reloading the replisome onto the template to reinitiate DNA replication. Here, we report the 2.0 A resolution crystal structure of E. coli PriB, revealing a dimer that consists of a single structural domain formed by two oligonucleotide/oligosaccharide binding (OB) folds. Structural similarity of PriB to single-stranded DNA binding proteins reveals insights into its mechanisms of DNA binding. The structure further establishes a putative protein interaction surface that may contribute to the role of PriB in primosome assembly by facilitating interactions with PriA and DnaT. This is the first high-resolution structure of a protein involved in oriC-independent replisome loading and provides unique insight into mechanisms of replication restart in E. coli.

About this Structure

1TXY is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of PriB, a component of the Escherichia coli replication restart primosome., Lopper M, Holton JM, Keck JL, Structure. 2004 Nov;12(11):1967-75. PMID:15530361

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