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1aoc

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Revision as of 08:14, 24 December 2014

JAPANESE HORSESHOE CRAB COAGULOGEN

Structural highlights

1aoc is a 2 chain structure with sequence from Tachypleus tridentatus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:	FirstGlance, OCA, RCSB, PDBsum

Function

[COAG_TACTR] Coagulogen is a gel-forming protein of hemolymph; it hinders the spread of invaders by immobilizing them.

Publication Abstract from PubMed

The clotting cascade system of the horseshoe crab (Limulus) is involved in both haemostasis and host defence. The cascade results in the conversion of coagulogen, a soluble protein, into an insoluble coagulin gel. The clotting enzyme excises the fragment peptide C from coagulogen, giving rise to aggregation of the monomers. The crystal structure of coagulogen reveals an elongated molecule that embraces the helical peptide C fragment. Cleavage and removal of the peptide C would expose an extended hydrophobic cove, which could interact with the hydrophobic edge of a second molecule, leading to a polymeric fibre. The C-terminal half of the coagulogen molecule exhibits a striking topological similarity to the neurotrophin nerve growth factor (NGF), providing the first evidence for a neurotrophin fold in invertebrates. Similarities between coagulogen and Spatzle, the Drosophila ligand of the receptor Toll, suggest that the neurotrophin fold might be considered more ancient and widespread than previously realized.

Crystal structure of a coagulogen, the clotting protein from horseshoe crab: a structural homologue of nerve growth factor.,Bergner A, Oganessyan V, Muta T, Iwanaga S, Typke D, Huber R, Bode W EMBO J. 1996 Dec 16;15(24):6789-97. PMID:9003754^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Bergner A, Oganessyan V, Muta T, Iwanaga S, Typke D, Huber R, Bode W. Crystal structure of a coagulogen, the clotting protein from horseshoe crab: a structural homologue of nerve growth factor. EMBO J. 1996 Dec 16;15(24):6789-97. PMID:9003754

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1aoc"

@@ Line 6: / Line 6: @@
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1aoc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aoc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1aoc RCSB], [http://www.ebi.ac.uk/pdbsum/1aoc PDBsum]</span></td></tr>
 </table>
+== Function ==
+[[http://www.uniprot.org/uniprot/COAG_TACTR COAG_TACTR]] Coagulogen is a gel-forming protein of hemolymph; it hinders the spread of invaders by immobilizing them.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==

1aoc

From Proteopedia

Revision as of 08:14, 24 December 2014

JAPANESE HORSESHOE CRAB COAGULOGEN

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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