1tyv
From Proteopedia
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|LIGAND= | |LIGAND= | ||
|ACTIVITY= | |ACTIVITY= | ||
| - | |GENE= PHAGE P22 GENE 9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= | + | |GENE= PHAGE P22 GENE 9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10754 Enterobacteria phage P22]) |
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tyv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tyv OCA], [http://www.ebi.ac.uk/pdbsum/1tyv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tyv RCSB]</span> | ||
}} | }} | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1TYV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ | + | 1TYV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_p22 Enterobacteria phage p22]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TYV OCA]. |
==Reference== | ==Reference== | ||
Crystal structure of phage P22 tailspike protein complexed with Salmonella sp. O-antigen receptors., Steinbacher S, Baxa U, Miller S, Weintraub A, Seckler R, Huber R, Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10584-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8855221 8855221] | Crystal structure of phage P22 tailspike protein complexed with Salmonella sp. O-antigen receptors., Steinbacher S, Baxa U, Miller S, Weintraub A, Seckler R, Huber R, Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10584-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8855221 8855221] | ||
| + | [[Category: Enterobacteria phage p22]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Yersinia phage py54]] | ||
[[Category: Huber, R.]] | [[Category: Huber, R.]] | ||
[[Category: Steinbacher, S.]] | [[Category: Steinbacher, S.]] | ||
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[[Category: viral adhesion protein]] | [[Category: viral adhesion protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:03:01 2008'' |
Revision as of 21:03, 30 March 2008
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| , resolution 1.8Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | PHAGE P22 GENE 9 (Enterobacteria phage P22) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURE OF TAILSPIKE-PROTEIN
Overview
The O-antigenic repeating units of lipopolysaccharides from Salmonella serogroups A, B, and D1 serve as receptors for the phage P22 tailspike protein, which also has receptor destroying endoglycosidase (endorhamnosidase) activity, integrating the functions of both hemagglutinin and neuraminidase in influenza virus. Crystal structures of the tailspike protein in complex with oligosaccharides, comprising two O-antigenic repeating units from Salmonella typhimurium, Salmonella enteritidis, and Salmonella typhi 253Ty were determined at 1.8 A resolution. The active-site topology with Asp-392, Asp-395, and Glu-359 as catalytic residues was identified. Kinetics of binding and cleavage suggest a role of the receptor destroying endorhamnosidase activity primarily for detachment of newly assembled phages.
About this Structure
1TYV is a Single protein structure of sequence from Enterobacteria phage p22. Full crystallographic information is available from OCA.
Reference
Crystal structure of phage P22 tailspike protein complexed with Salmonella sp. O-antigen receptors., Steinbacher S, Baxa U, Miller S, Weintraub A, Seckler R, Huber R, Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10584-8. PMID:8855221
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