1tyw
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 1tyw |SIZE=350|CAPTION= <scene name='initialview01'>1tyw</scene>, resolution 1.8Å | |PDB= 1tyw |SIZE=350|CAPTION= <scene name='initialview01'>1tyw</scene>, resolution 1.8Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=GLC:GLUCOSE'>GLC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=RAM:RHAMNOSE'>RAM</scene>, <scene name='pdbligand=TYV:TYVELOSE'>TYV</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= PHAGE P22 GENE 9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= SALMONELLA TYPHIMURIUM PHAGE P22]) | |GENE= PHAGE P22 GENE 9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= SALMONELLA TYPHIMURIUM PHAGE P22]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tyw OCA], [http://www.ebi.ac.uk/pdbsum/1tyw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tyw RCSB]</span> | ||
}} | }} | ||
| Line 32: | Line 35: | ||
[[Category: viral adhesion protein]] | [[Category: viral adhesion protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:03:00 2008'' |
Revision as of 21:03, 30 March 2008
| |||||||
| , resolution 1.8Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , , | ||||||
| Gene: | PHAGE P22 GENE 9 (SALMONELLA TYPHIMURIUM PHAGE P22) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURE OF TAILSPIKE-PROTEIN
Overview
The O-antigenic repeating units of lipopolysaccharides from Salmonella serogroups A, B, and D1 serve as receptors for the phage P22 tailspike protein, which also has receptor destroying endoglycosidase (endorhamnosidase) activity, integrating the functions of both hemagglutinin and neuraminidase in influenza virus. Crystal structures of the tailspike protein in complex with oligosaccharides, comprising two O-antigenic repeating units from Salmonella typhimurium, Salmonella enteritidis, and Salmonella typhi 253Ty were determined at 1.8 A resolution. The active-site topology with Asp-392, Asp-395, and Glu-359 as catalytic residues was identified. Kinetics of binding and cleavage suggest a role of the receptor destroying endorhamnosidase activity primarily for detachment of newly assembled phages.
About this Structure
1TYW is a Single protein structure of sequence from Salmonella typhimurium phage p22. Full crystallographic information is available from OCA.
Reference
Crystal structure of phage P22 tailspike protein complexed with Salmonella sp. O-antigen receptors., Steinbacher S, Baxa U, Miller S, Weintraub A, Seckler R, Huber R, Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10584-8. PMID:8855221
Page seeded by OCA on Mon Mar 31 00:03:00 2008
