1tze
From Proteopedia
(Difference between revisions)
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|PDB= 1tze |SIZE=350|CAPTION= <scene name='initialview01'>1tze</scene>, resolution 2.1Å | |PDB= 1tze |SIZE=350|CAPTION= <scene name='initialview01'>1tze</scene>, resolution 2.1Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=NH2:AMINO GROUP'>NH2</scene> | + | |LIGAND= <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= GRB2 55-152 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= GRB2 55-152 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tze OCA], [http://www.ebi.ac.uk/pdbsum/1tze PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tze RCSB]</span> | ||
}} | }} | ||
'''SIGNAL TRANSDUCTION ADAPTOR GROWTH FACTOR, GRB2 SH2 DOMAIN COMPLEXED WITH PHOSPHOTYROSYL HEPTAPEPTIDE LYS-PRO-PHE-PTYR-VAL-ASN-VAL-NH2 (KFPPYVNC-NH2)''' | '''SIGNAL TRANSDUCTION ADAPTOR GROWTH FACTOR, GRB2 SH2 DOMAIN COMPLEXED WITH PHOSPHOTYROSYL HEPTAPEPTIDE LYS-PRO-PHE-PTYR-VAL-ASN-VAL-NH2 (KFPPYVNC-NH2)''' | ||
| - | |||
| - | ==Disease== | ||
| - | Known diseases associated with this structure: Central hypoventilation syndrome, congenital OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=100790 100790]], Haddad syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=100790 100790]] | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Grutter, M G.]] | [[Category: Grutter, M G.]] | ||
[[Category: Rahuel, J.]] | [[Category: Rahuel, J.]] | ||
| - | [[Category: NH2]] | ||
[[Category: complex (signal transduction/peptide)]] | [[Category: complex (signal transduction/peptide)]] | ||
[[Category: phosphotyrosyl heptapeptic ligand]] | [[Category: phosphotyrosyl heptapeptic ligand]] | ||
[[Category: signal transduction adaptor growth factor bound protein 2 (grb2) src homology 2 domain (sh2)]] | [[Category: signal transduction adaptor growth factor bound protein 2 (grb2) src homology 2 domain (sh2)]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:03:16 2008'' |
Revision as of 21:03, 30 March 2008
| |||||||
| , resolution 2.1Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Gene: | GRB2 55-152 (Homo sapiens) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
SIGNAL TRANSDUCTION ADAPTOR GROWTH FACTOR, GRB2 SH2 DOMAIN COMPLEXED WITH PHOSPHOTYROSYL HEPTAPEPTIDE LYS-PRO-PHE-PTYR-VAL-ASN-VAL-NH2 (KFPPYVNC-NH2)
About this Structure
1TZE is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structural basis for specificity of Grb2-SH2 revealed by a novel ligand binding mode., Rahuel J, Gay B, Erdmann D, Strauss A, Garcia-Echeverria C, Furet P, Caravatti G, Fretz H, Schoepfer J, Grutter MG, Nat Struct Biol. 1996 Jul;3(7):586-9. PMID:8673601
Page seeded by OCA on Mon Mar 31 00:03:16 2008
