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1u11

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|PDB= 1u11 |SIZE=350|CAPTION= <scene name='initialview01'>1u11</scene>, resolution 1.55&Aring;
|PDB= 1u11 |SIZE=350|CAPTION= <scene name='initialview01'>1u11</scene>, resolution 1.55&Aring;
|SITE=
|SITE=
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|LIGAND= <scene name='pdbligand=CIT:CITRIC ACID'>CIT</scene>
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|LIGAND= <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>
|ACTIVITY=
|ACTIVITY=
|GENE= PurE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=435 Acetobacter aceti])
|GENE= PurE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=435 Acetobacter aceti])
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|DOMAIN=
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u11 OCA], [http://www.ebi.ac.uk/pdbsum/1u11 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1u11 RCSB]</span>
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}}
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[[Category: Mill, C P.]]
[[Category: Mill, C P.]]
[[Category: Settembre, E C.]]
[[Category: Settembre, E C.]]
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[[Category: CIT]]
 
[[Category: acidophile]]
[[Category: acidophile]]
[[Category: protein stability]]
[[Category: protein stability]]
[[Category: pure]]
[[Category: pure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:25:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:03:58 2008''

Revision as of 21:03, 30 March 2008

Image:1u11.gif


PDB ID 1u11

Drag the structure with the mouse to rotate
, resolution 1.55Å
Ligands:
Gene: PurE (Acetobacter aceti)
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



PurE (N5-carboxyaminoimidazole Ribonucleotide Mutase) from the acidophile Acetobacter aceti


Overview

The crystal structure of Acetobacter aceti PurE was determined to a resolution of 1.55 A and is compared with the known structures of the class I PurEs from a mesophile, Escherichia coli, and a thermophile, Thermotoga maritima. Analyses of the general factors that increase protein stability are examined as potential explanations for the acid stability of A. aceti PurE. Increased inter-subunit hydrogen bonding and an increased number of arginine-containing salt bridges appear to account for the bulk of the increased acid stability. A chain of histidines linking two active sites is discussed in the context of the proton transfers catalyzed by the enzyme.

About this Structure

1U11 is a Protein complex structure of sequences from Acetobacter aceti. Full crystallographic information is available from OCA.

Reference

Acidophilic adaptations in the structure of Acetobacter aceti N5-carboxyaminoimidazole ribonucleotide mutase (PurE)., Settembre EC, Chittuluru JR, Mill CP, Kappock TJ, Ealick SE, Acta Crystallogr D Biol Crystallogr. 2004 Oct;60(Pt 10):1753-60. Epub 2004, Sep 23. PMID:15388921

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