1u4f
From Proteopedia
| Line 7: | Line 7: | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= Kcnj2, IRK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | |GENE= Kcnj2, IRK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1p7b|1P7B]], [[1n9p|1N9P]], [[1u4e|1U4E]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u4f OCA], [http://www.ebi.ac.uk/pdbsum/1u4f PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1u4f RCSB]</span> | ||
}} | }} | ||
| Line 34: | Line 37: | ||
[[Category: rectification]] | [[Category: rectification]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:05:16 2008'' |
Revision as of 21:05, 30 March 2008
| |||||||
| , resolution 2.41Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | Kcnj2, IRK1 (Mus musculus) | ||||||
| Related: | 1P7B, 1N9P, 1U4E
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of Cytoplasmic Domains of IRK1 (Kir2.1) channel
Overview
N- and C-terminal cytoplasmic domains of inwardly rectifying K (Kir) channels control the ion-permeation pathway through diverse interactions with small molecules and protein ligands in the cytoplasm. Two new crystal structures of the cytoplasmic domains of Kir2.1 (Kir2.1(L)) and the G protein-sensitive Kir3.1 (Kir3.1(S)) channels in the absence of PIP(2) show the cytoplasmic ion-permeation pathways occluded by four cytoplasmic loops that form a girdle around the central pore (G-loop). Significant flexibility of the pore-facing G-loop of Kir2.1(L) and Kir3.1(S) suggests a possible role as a diffusion barrier between cytoplasmic and transmembrane pores. Consistent with this, mutations of the G-loop disrupted gating or inward rectification. Structural comparison shows a di-aspartate cluster on the distal end of the cytoplasmic pore of Kir2.1(L) that is important for modulating inward rectification. Taken together, these results suggest the cytoplasmic domains of Kir channels undergo structural changes to modulate gating and inward rectification.
About this Structure
1U4F is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification., Pegan S, Arrabit C, Zhou W, Kwiatkowski W, Collins A, Slesinger PA, Choe S, Nat Neurosci. 2005 Mar;8(3):279-87. Epub 2005 Feb 20. PMID:15723059
Page seeded by OCA on Mon Mar 31 00:05:16 2008
