Sandbox Reserved 959

From Proteopedia

Revision as of 09:34, 23 December 2014

Introduction

Defensins (DEF) are a family of protein which are involved in host defenses in the epithelia of mucosal surfaces such as those of the intestin, respiratory tract, urinary tract, and vagina. There are antimicrobial and cytotoxic. All the protein of the family are distinguished by a cystein motif and are encoded on the chromozome 8 ^[1]. There are many defensin but in this article we will focus on the defensin alpha 1. The defensin alpha 1 is a polypeptide which are found in the microbicidal granules of neutrophils. They are syntetisize in the Paneth cell, which plays a role in the defense process. ^[2]It plays a role in phagocite-mediated host defense.
In this article, we will focus on the action of the alpha defensin 1 against the ' ' trypanosoma cruzy ' '.

spinqualitylabelsall models PDB ID 2pm4 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Biological role DEF are known to play a role in the in the initiation of innate immune responses to some microbial pathogens. For example the alpha defensin 1 have a role against the bacteria "Trypanosoma cruzi"."Trypanosoma cruzy" or "Cruzy" debilitats Chagas disease, which affects millions of people and products significant morbidity and mortality. The defensine alpha 1 are secreted by the HCT116 cells (which are Paneth cells), when they are infect by "Cruzy". They reduces the infection making damage of the flagella structure. This damage inhibit parasite motility and reduce cellular infection. This reaction is introduce in the following drawing. Mevalonate Pathway. Note the early stage at which the statins interfere in the pathway [3]