3tjy

From Proteopedia

(Difference between revisions)

Revision as of 08:46, 4 August 2016

Structure of the Pto-binding domain of HopPmaL generated by limited chymotrypsin digestion

Structural highlights

3tjy is a 1 chain structure with sequence from Pseudomonas syringae pv. maculicola str. es4326. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
NonStd Res:
Related:	3svi
Gene:	hopAB3, hopPmaL (Pseudomonas syringae pv. maculicola str. ES4326)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[HPAB3_PSEYM] Effector protein involved in gene-for-gene resistance in tomato plants. It is recognized by the host Pto resistance protein and elicits Pto and Prf-dependent hypersensitive response (HR) and programmed cell death (PCD), resulting in host immunity. In susceptible plants, promotes virulence, in part, by enhancing the development of disease symptoms and bacterial growth.

Publication Abstract from PubMed

HopPmaL is a member of the HopAB family of type III effectors present in the phytopathogen Pseudomonas syringae. Using both X-ray crystallography and solution nuclear magnetic resonance, we demonstrate that HopPmaL contains two structurally homologous yet functionally distinct domains. The N-terminal domain corresponds to the previously described Pto-binding domain, while the previously uncharacterised C-terminal domain spans residues 308-385. While structurally similar, these domains do not share significant sequence similarity and most importantly demonstrate significant differences in key residues involved in host protein recognition, suggesting that each of them targets a different host protein.

Structural Analysis of HopPmaL Reveals the Presence of a Second Adaptor Domain Common to the HopAB Family of Pseudomonas syringae Type III Effectors.,Singer AU, Wu B, Yee A, Houliston S, Xu X, Cui H, Skarina T, Garcia M, Semesi A, Arrowsmith CH, Savchenko A Biochemistry. 2012 Jan 10;51(1):1-3. Epub 2011 Dec 28. PMID:22191472^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Singer AU, Wu B, Yee A, Houliston S, Xu X, Cui H, Skarina T, Garcia M, Semesi A, Arrowsmith CH, Savchenko A. Structural Analysis of HopPmaL Reveals the Presence of a Second Adaptor Domain Common to the HopAB Family of Pseudomonas syringae Type III Effectors. Biochemistry. 2012 Jan 10;51(1):1-3. Epub 2011 Dec 28. PMID:22191472 doi:10.1021/bi2013883

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3tjy"

@@ Line 1: / Line 1: @@
 ==Structure of the Pto-binding domain of HopPmaL generated by limited chymotrypsin digestion==
 <StructureSection load='3tjy' size='340' side='right' caption='[[3tjy]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
@@ Line 7: / Line 8: @@
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3svi|3svi]]</td></tr>
 <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">hopAB3, hopPmaL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=629265 Pseudomonas syringae pv. maculicola str. ES4326])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tjy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tjy RCSB], [http://www.ebi.ac.uk/pdbsum/3tjy PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tjy OCA], [http://pdbe.org/3tjy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3tjy RCSB], [http://www.ebi.ac.uk/pdbsum/3tjy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3tjy ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 19: / Line 20: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 3tjy" style="background-color:#fffaf0;"></div>
 ==See Also==

3tjy

From Proteopedia

Revision as of 08:46, 4 August 2016

Structure of the Pto-binding domain of HopPmaL generated by limited chymotrypsin digestion

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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