1w50
From Proteopedia
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|PDB= 1w50 |SIZE=350|CAPTION= <scene name='initialview01'>1w50</scene>, resolution 1.75Å | |PDB= 1w50 |SIZE=350|CAPTION= <scene name='initialview01'>1w50</scene>, resolution 1.75Å | ||
|SITE= <scene name='pdbsite=AC2:Iod+Binding+Site+For+Chain+A'>AC2</scene> | |SITE= <scene name='pdbsite=AC2:Iod+Binding+Site+For+Chain+A'>AC2</scene> | ||
| - | |LIGAND= <scene name='pdbligand=IOD:IODIDE ION'>IOD</scene> | + | |LIGAND= <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w50 OCA], [http://www.ebi.ac.uk/pdbsum/1w50 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1w50 RCSB]</span> | ||
}} | }} | ||
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[[Category: Vuillard, L.]] | [[Category: Vuillard, L.]] | ||
[[Category: Yon, J.]] | [[Category: Yon, J.]] | ||
| - | [[Category: IOD]] | ||
[[Category: alternative splicing]] | [[Category: alternative splicing]] | ||
[[Category: alzheimer's disease]] | [[Category: alzheimer's disease]] | ||
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[[Category: zymogen]] | [[Category: zymogen]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:31:15 2008'' |
Revision as of 21:31, 30 March 2008
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| , resolution 1.75Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | |||||||
| Ligands: | |||||||
| Activity: | Memapsin 2, with EC number 3.4.23.46 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
APO STRUCTURE OF BACE (BETA SECRETASE)
Overview
Human BACE, also known as beta-secretase, shows promise as a potential therapeutic target for Alzheimer's disease. We determined the apo structure of BACE to 1.75 A, and a structure of a hydroxyethylamine inhibitor complex derived by soaking. These show significant active-site movements compared to previously described BACE structures. Additionally, the structures reveal two pockets that could be targeted by structure-based drug design.
About this Structure
1W50 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Apo and inhibitor complex structures of BACE (beta-secretase)., Patel S, Vuillard L, Cleasby A, Murray CW, Yon J, J Mol Biol. 2004 Oct 15;343(2):407-16. PMID:15451669
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