4d6q
From Proteopedia
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==crystal structure of human JMJD2D in complex with 2,4-PDCA== | ==crystal structure of human JMJD2D in complex with 2,4-PDCA== | ||
<StructureSection load='4d6q' size='340' side='right' caption='[[4d6q]], [[Resolution|resolution]] 1.29Å' scene=''> | <StructureSection load='4d6q' size='340' side='right' caption='[[4d6q]], [[Resolution|resolution]] 1.29Å' scene=''> | ||
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PD2:PYRIDINE-2,4-DICARBOXYLIC+ACID'>PD2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PD2:PYRIDINE-2,4-DICARBOXYLIC+ACID'>PD2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4d6r|4d6r]], [[4d6s|4d6s]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4d6r|4d6r]], [[4d6s|4d6s]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d6q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d6q RCSB], [http://www.ebi.ac.uk/pdbsum/4d6q PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d6q OCA], [http://pdbe.org/4d6q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d6q RCSB], [http://www.ebi.ac.uk/pdbsum/4d6q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4d6q ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/KDM4D_HUMAN KDM4D_HUMAN]] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.<ref>PMID:16603238</ref> | [[http://www.uniprot.org/uniprot/KDM4D_HUMAN KDM4D_HUMAN]] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.<ref>PMID:16603238</ref> | ||
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| + | ==See Also== | ||
| + | *[[Jumonji domain-containing protein|Jumonji domain-containing protein]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 04:14, 5 August 2016
crystal structure of human JMJD2D in complex with 2,4-PDCA
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