2mp1
From Proteopedia
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| - | ''' | + | ==Solution structure of the human chemokine CCL19== |
| - | + | <StructureSection load='2mp1' size='340' side='right' caption='[[2mp1]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2mp1]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MP1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MP1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mp1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mp1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mp1 RCSB], [http://www.ebi.ac.uk/pdbsum/2mp1 PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | [[ | + | [[http://www.uniprot.org/uniprot/CCL19_HUMAN CCL19_HUMAN]] May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.<ref>PMID:9498785</ref> |
| - | [[Category: Gabel-Eissens, S | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Veldkamp, C | + | </StructureSection> |
| + | [[Category: Gabel-Eissens, S J]] | ||
| + | [[Category: Gillitzer, M L]] | ||
| + | [[Category: Peterson, F C]] | ||
| + | [[Category: Veldkamp, C T]] | ||
| + | [[Category: Ccl19]] | ||
| + | [[Category: Ccl21]] | ||
| + | [[Category: Ccr7]] | ||
| + | [[Category: Chemokine receptor]] | ||
| + | [[Category: Chemokine]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 14:03, 10 June 2015
Solution structure of the human chemokine CCL19
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