2msy

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'''Unreleased structure'''
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==Solution structure of Hox homeodomain==
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<StructureSection load='2msy' size='340' side='right' caption='[[2msy]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2msy]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MSY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MSY FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2msy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2msy OCA], [http://pdbe.org/2msy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2msy RCSB], [http://www.ebi.ac.uk/pdbsum/2msy PDBsum]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/HXC9_HUMAN HXC9_HUMAN]] Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The Hox DNA binding domain, the homeodomain, plays critical roles in genetic control of development and cell fate determination. The variable regulatory functions of Hox proteins are accomplished by binding to target DNA sequences and collaborating protein partners that includes human high mobility group B1 (HMGB1). To better understand the interaction between Hox and HMGB1 and the facilitation of Hox-DNA binding by HMGB1, we solved the solution structure of the homeodomain of Hox including the N-terminal arm region (Hoxc9DBD hereafter). In addition, the details of the interaction between these two proteins, as well as DNA binding of the Hox-HMGB1 complex, were investigated by NMR, ITC, and EMSA. The results suggest that binding of the HMGB1 A-box to Hoxc9DBD makes the loop-1 (loop preceding helix-2 of Hoxc9DBD) more access to DNA backbone, which facilitate Hox-DNA binding with enhanced affinity.
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The entry 2msy is ON HOLD until Paper Publication
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Structural insight into the interaction between the Hox and HMGB1 and understanding of the HMGB1-enhancing effect of Hox-DNA binding.,Kim HH, Park SJ, Han JH, Pathak C, Cheong HK, Lee BJ Biochim Biophys Acta. 2015 May;1854(5):449-59. doi: 10.1016/j.bbapap.2015.02.009., Epub 2015 Feb 20. PMID:25707357<ref>PMID:25707357</ref>
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Authors: Kim, H., Park, S., Han, J., Lee, B.
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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Description: Solution structure of Hox homeodomain
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<div class="pdbe-citations 2msy" style="background-color:#fffaf0;"></div>
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[[Category: Unreleased Structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Han, J]]
[[Category: Kim, H]]
[[Category: Kim, H]]
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[[Category: Han, J]]
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[[Category: Lee, B]]
[[Category: Park, S]]
[[Category: Park, S]]
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[[Category: Lee, B]]
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[[Category: Homeodomain]]
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[[Category: Transcription]]
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[[Category: Transcription factor]]

Revision as of 07:32, 7 October 2015

Solution structure of Hox homeodomain

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