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2mu4
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Structure of F. tularensis Virulence Determinant== |
| + | <StructureSection load='2mu4' size='340' side='right' caption='[[2mu4]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2mu4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MU4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MU4 FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mu4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mu4 RCSB], [http://www.ebi.ac.uk/pdbsum/2mu4 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Tularemia is a potentially fatal bacterial infection caused by Francisella tularensis, and is endemic to North America and many parts of northern Europe and Asia. The outer membrane lipoprotein, Flpp3, has been identified as a virulence determinant as well as a potential subunit template for vaccine development. Here we present the first structure for the soluble domain of Flpp3 from the highly infectious Type A SCHU S4 strain, derived through high-resolution solution nuclear magnetic resonance (NMR) spectroscopy; the first structure of a lipoprotein from the genus Francisella. The Flpp3 structure demonstrates a globular protein with an electrostatically polarized surface containing an internal cavity-a putative binding site based on the structurally homologous Bet v1 protein family of allergens. NMR-based relaxation studies suggest loop regions that potentially modulate access to the internal cavity. The Flpp3 structure may add to the understanding of F. tularensis virulence and contribute to the development of effective vaccines. | ||
| - | + | NMR Structure of Francisella tularensis Virulence Determinant Reveals Structural Homology to Bet v1 Allergen Proteins.,Zook J, Mo G, Sisco NJ, Craciunescu FM, Hansen DT, Baravati B, Cherry BR, Sykes K, Wachter R, Van Horn WD, Fromme P Structure. 2015 Jun 2;23(6):1116-22. doi: 10.1016/j.str.2015.03.025. Epub 2015, May 21. PMID:26004443<ref>PMID:26004443</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Craciunescu, F | + | </StructureSection> |
| - | [[Category: | + | [[Category: Baravati, B B.B]] |
| - | [[Category: | + | [[Category: Cherry, B B.C]] |
| - | [[Category: | + | [[Category: Craciunescu, F F.C]] |
| - | [[Category: Mo, G | + | [[Category: Fromme, P P.F]] |
| - | [[Category: | + | [[Category: Hansen, D D.H]] |
| - | [[Category: | + | [[Category: Horn, W W.V H.Van]] |
| - | [[Category: | + | [[Category: Mo, G G.M]] |
| + | [[Category: Sisco, N N.S]] | ||
| + | [[Category: Zook, J J.D Z]] | ||
| + | [[Category: Lipoprotein]] | ||
| + | [[Category: Membrane protein]] | ||
Revision as of 13:57, 10 June 2015
Structure of F. tularensis Virulence Determinant
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