2mux
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==SUMO2 non-covalently interacts with USP25 and downregulates its activity== | |
| - | + | <StructureSection load='2mux' size='340' side='right' caption='[[2mux]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2mux]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MUX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MUX FirstGlance]. <br> | |
| - | + | </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mux FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mux OCA], [http://pdbe.org/2mux PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mux RCSB], [http://www.ebi.ac.uk/pdbsum/2mux PDBsum]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/UBP25_HUMAN UBP25_HUMAN]] Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains. The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Ubiquitinyl hydrolase 1]] | ||
| + | [[Category: Shi, L]] | ||
| + | [[Category: Wen, Y]] | ||
[[Category: Zhang, N]] | [[Category: Zhang, N]] | ||
| - | [[Category: | + | [[Category: Hydrolase]] |
| - | + | ||
Revision as of 18:36, 12 May 2016
SUMO2 non-covalently interacts with USP25 and downregulates its activity
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