2mvt

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'''Unreleased structure'''
 
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The entry 2mvt is ON HOLD until Paper Publication
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==Solution structure of scoloptoxin SSD609 from Scolopendra mutilans==
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<StructureSection load='2mvt' size='340' side='right' caption='[[2mvt]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2mvt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chinese_red-headed_centipede Chinese red-headed centipede]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MVT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MVT FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mvt OCA], [http://pdbe.org/2mvt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mvt RCSB], [http://www.ebi.ac.uk/pdbsum/2mvt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mvt ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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KCNE1 is a single-span transmembrane auxiliary protein that modulates the voltage-gated potassium channel KCNQ1. The KCNQ1/KCNE1 complex in cardiomyocytes exhibited slow activated potassium (I(ks)) currents. Recently, a novel 47-residue polypeptide toxin SSD609 was purified from Scolopendra subspinipes dehaani venom and showed I(ks) current inhibition. Here, chemically synthesized SSD609 was shown to exert I(ks) inhibition in extracted guinea pig cardiomyocytes and KCNQ1/KCNE1 current attenuation in CHO cells. The K(+) current attenuation of SSD609 showed decent selectivity among different auxiliary subunits. Solution nuclear magnetic resonance analysis of SSD609 revealed a distinctive three-helix conformation that was stabilized by a new disulfide bonding pattern as well as segregated surface charge distribution. Structure-activity studies demonstrated that negatively charged Glu19 in the amphipathic extracellular helix of KCNE1 was the key residue that interacted with SSD609. The distinctive three-helix centipede toxin SSD609 is known to be the first polypeptide toxin acting on channel auxiliary subunit KCNE1, which suggests a new type of pharmacological regulation for ion channels in cardiomyocytes.
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Authors: Wu, F., Sun, P., Wang, C., He, Y., Zhang, L., Tian, C.
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A distinct three-helix centipede toxin SSD609 inhibits I(ks) channels by interacting with the KCNE1 auxiliary subunit.,Sun P, Wu F, Wen M, Yang X, Wang C, Li Y, He S, Zhang L, Zhang Y, Tian C Sci Rep. 2015 Aug 26;5:13399. doi: 10.1038/srep13399. PMID:26307551<ref>PMID:26307551</ref>
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Description: Solution structure of scoloptoxin SSD609 from Scolopendra mutilans
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Sun, P]]
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<div class="pdbe-citations 2mvt" style="background-color:#fffaf0;"></div>
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[[Category: Zhang, L]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Chinese red-headed centipede]]
[[Category: He, Y]]
[[Category: He, Y]]
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[[Category: Wang, C]]
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[[Category: Sun, P]]
[[Category: Tian, C]]
[[Category: Tian, C]]
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[[Category: Wang, C]]
[[Category: Wu, F]]
[[Category: Wu, F]]
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[[Category: Zhang, L]]
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[[Category: Toxin]]

Revision as of 15:03, 16 November 2017

Solution structure of scoloptoxin SSD609 from Scolopendra mutilans

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