1wms
From Proteopedia
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|PDB= 1wms |SIZE=350|CAPTION= <scene name='initialview01'>1wms</scene>, resolution 1.25Å | |PDB= 1wms |SIZE=350|CAPTION= <scene name='initialview01'>1wms</scene>, resolution 1.25Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5 | + | |LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5'-DIPHOSPHATE'>GDP</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= Rab9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= Rab9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
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[[Category: gtpase]] | [[Category: gtpase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 14:07:35 2008'' |
Revision as of 12:07, 23 March 2008
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| , resolution 1.25Å | |||||||
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| Ligands: | |||||||
| Gene: | Rab9 (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
High resolution crystal structure of human Rab9 GTPase: a novel antiviral drug target
Overview
Rab GTPases and their effectors facilitate vesicular transport by tethering donor vesicles to their respective target membranes. Rab9 mediates late endosome to trans-Golgi transport and has recently been found to be a key cellular component for human immunodeficiency virus-1, Ebola, Marburg, and measles virus replication, suggesting that it may be a novel target in the development of broad spectrum antiviral drugs. As part of our structure-based drug design program, we have determined the crystal structure of a C-terminally truncated human Rab9 (residues 1-177) to 1.25-A resolution. The overall structure shows a characteristic nucleotide binding fold consisting of a six-stranded beta-sheet surrounded by five alpha-helices with a tightly bound GDP molecule in the active site. Structure-based sequence alignment of Rab9 with other Rab proteins reveals that its active site consists of residues highly conserved in the Rab GTPase family, implying a common catalytic mechanism. However, Rab9 contains seven regions that are significantly different in conformation from other Rab proteins. Some of those regions coincide with putative effector-binding sites and switch I and switch II regions identified by structure/sequence alignments. The Rab9 structure at near atomic resolution provides an excellent model for structure-based antiviral drug design.
About this Structure
1WMS is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
High resolution crystal structure of human Rab9 GTPase: a novel antiviral drug target., Chen L, DiGiammarino E, Zhou XE, Wang Y, Toh D, Hodge TW, Meehan EJ, J Biol Chem. 2004 Sep 17;279(38):40204-8. Epub 2004 Jul 19. PMID:15263003
Page seeded by OCA on Sun Mar 23 14:07:35 2008
Categories: Homo sapiens | Single protein | Chen, L. | DiGiammarino, E. | Hodge, T W. | Meehan, E J. | Toh, D. | Wang, Y. | Zhou, X E. | GDP | Gtpase
