1wq6

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|PDB= 1wq6 |SIZE=350|CAPTION= <scene name='initialview01'>1wq6</scene>, resolution 2.00&Aring;
|PDB= 1wq6 |SIZE=350|CAPTION= <scene name='initialview01'>1wq6</scene>, resolution 2.00&Aring;
|SITE=
|SITE=
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|LIGAND=
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
|ACTIVITY=
|ACTIVITY=
|GENE= AML1/ETO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
|GENE= AML1/ETO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wq6 OCA], [http://www.ebi.ac.uk/pdbsum/1wq6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1wq6 RCSB]</span>
}}
}}
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[[Category: nhr2]]
[[Category: nhr2]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:00:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:39:36 2008''

Revision as of 21:39, 30 March 2008

Image:1wq6.gif


PDB ID 1wq6

Drag the structure with the mouse to rotate
, resolution 2.00Å
Ligands:
Gene: AML1/ETO (Homo sapiens)
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



The tetramer structure of the nervy homolgy two (NHR2) domain of AML1-ETO is critical for AML1-ETO'S activity


Overview

AML1/ETO is the chimeric protein resulting from the t(8;21) in acute myeloid leukemia. The Nervy homology 2 (NHR2) domain in ETO mediates oligomerization and AML1/ETO's interactions with ETO, MTGR1, and MTG16, and with the corepressor molecules mSin3A and HDAC1 and HDAC3. We solved the NHR2 domain structure and found it to be an alpha-helical tetramer. We show that oligomerization contributes to AML1/ETO's inhibition of granulocyte differentiation, is essential for its ability to enhance the clonogenic potential of primary mouse bone marrow cells, and affects AML1/ETO's activity on several endogenous genes. Oligomerization is also required for AML1/ETO's interactions with ETO, MTGR1, and MTG16, but not with other corepressor molecules.

About this Structure

1WQ6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity., Liu Y, Cheney MD, Gaudet JJ, Chruszcz M, Lukasik SM, Sugiyama D, Lary J, Cole J, Dauter Z, Minor W, Speck NA, Bushweller JH, Cancer Cell. 2006 Apr;9(4):249-60. PMID:16616331

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