4cg4

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'''Unreleased structure'''
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==Crystal structure of the CHS-B30.2 domains of TRIM20==
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<StructureSection load='4cg4' size='340' side='right' caption='[[4cg4]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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The entry 4cg4 is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4cg4]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CG4 FirstGlance]. <br>
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Authors: Weinert, C., Morger, D., Djekic, A., Mittl, P.R.E., Gruetter, M.G.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DHL:2-AMINO-ETHANETHIOL'>DHL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
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Description: Crystal structure of the CHS-B30.2 domains of TRIM20
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cg4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cg4 RCSB], [http://www.ebi.ac.uk/pdbsum/4cg4 PDBsum]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Gruetter, M.G]]
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== Disease ==
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[[http://www.uniprot.org/uniprot/MEFV_HUMAN MEFV_HUMAN]] Defects in MEFV are the cause of familial Mediterranean fever autosomal recessive (ARFMF) [MIM:[http://omim.org/entry/249100 249100]]. ARFMF is an inherited disorder characterized by recurrent episodic fever, serosal inflammation and pain in the abdomen, chest or joints. ARFMF is frequently complicated by amyloidosis, which leads to renal failure and can be prophylactically treated with colchicine. ARFMF primarily affects ancestral ethnic groups living around the Mediterranean basin: North African Jews, Armenians, Arabs and Turks. The disease is also distributed in other populations including Greeks, Cypriots, Italians and Spanish, although at a lower prevalence.<ref>PMID:9288758</ref> <ref>PMID:9288094</ref> <ref>PMID:11470495</ref> <ref>PMID:12384939</ref> <ref>PMID:9668175</ref> <ref>PMID:10024914</ref> <ref>PMID:10090880</ref> <ref>PMID:10364520</ref> <ref>PMID:10234504</ref> <ref>PMID:10612841</ref> <ref>PMID:10854105</ref> <ref>PMID:10842288</ref> <ref>PMID:15024744</ref> <ref>PMID:16378925</ref> <ref>PMID:16730661</ref> Defects in MEFV are the cause of familial Mediterranean fever autosomal dominant (ADFMF) [MIM:[http://omim.org/entry/134610 134610]]. ADFMF is characterized by periodic fever, serosal inflammation and pain in the abdomen, chest or joints as seen also in the autosomal recessive form of the disease. It is associated with renal amyloidosis and characterized by colchicine unresponsiveness.
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== Function ==
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[[http://www.uniprot.org/uniprot/MEFV_HUMAN MEFV_HUMAN]] Probably controls the inflammatory response in myelomonocytic cells at the level of the cytoskeleton organization.<ref>PMID:10807793</ref> <ref>PMID:11468188</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Djekic, A]]
[[Category: Djekic, A]]
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[[Category: Weinert, C]]
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[[Category: Gruetter, M G]]
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[[Category: Mittl, P.R.E]]
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[[Category: Mittl, P R.E]]
[[Category: Morger, D]]
[[Category: Morger, D]]
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[[Category: Weinert, C]]
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[[Category: Actin-binding protein]]
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[[Category: Familial mediterranean fever]]

Revision as of 11:32, 30 April 2015

Crystal structure of the CHS-B30.2 domains of TRIM20

4cg4, resolution 2.40Å

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