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4d0g

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'''Unreleased structure'''
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==Structure of Rab14 in complex with Rab-Coupling Protein (RCP)==
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<StructureSection load='4d0g' size='340' side='right' caption='[[4d0g]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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The entry 4d0g is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4d0g]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D0G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D0G FirstGlance]. <br>
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Authors: Lall, P., Khan, A.R.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d0g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d0g RCSB], [http://www.ebi.ac.uk/pdbsum/4d0g PDBsum]</span></td></tr>
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Description: Structure of Rab14 in complex with Rab-Coupling Protein (RCP)
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</table>
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[[Category: Unreleased Structures]]
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== Function ==
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[[http://www.uniprot.org/uniprot/RAB14_HUMAN RAB14_HUMAN]] Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion.<ref>PMID:22595670</ref> [[http://www.uniprot.org/uniprot/RFIP1_HUMAN RFIP1_HUMAN]] A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis.<ref>PMID:11786538</ref> <ref>PMID:15181150</ref> <ref>PMID:15355514</ref> <ref>PMID:16920206</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Khan, A R]]
[[Category: Lall, P]]
[[Category: Lall, P]]
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[[Category: Khan, A.R]]
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[[Category: Effector recruitment]]
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[[Category: Endosomal trafficking]]
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[[Category: Hydrolase]]
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[[Category: Rab14 gtpase]]

Revision as of 12:14, 20 May 2015

Structure of Rab14 in complex with Rab-Coupling Protein (RCP)

4d0g, resolution 2.50Å

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