1jyh
From Proteopedia
(Difference between revisions)
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<StructureSection load='1jyh' size='340' side='right' caption='[[1jyh]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='1jyh' size='340' side='right' caption='[[1jyh]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1jyh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1jyh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JYH FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gyrI (sbmC,yeeB) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gyrI (sbmC,yeeB) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jyh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jyh RCSB], [http://www.ebi.ac.uk/pdbsum/1jyh PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/1jyh TOPSAN]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jyh OCA], [http://pdbe.org/1jyh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jyh RCSB], [http://www.ebi.ac.uk/pdbsum/1jyh PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/1jyh TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[http://www.uniprot.org/uniprot/ | + | [[http://www.uniprot.org/uniprot/SBMC_ECOLI SBMC_ECOLI]] Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell. Protects cells against the natural plasmid-encoded toxins microcin B17 (MccB17) and CcdB, and synthetic quinolones. Can also protect cells against alkylating agents that act independently of DNA gyrase, suggesting a more general role in protecting cells against DNA damage.<ref>PMID:11850398</ref> <ref>PMID:13680098</ref> <ref>PMID:8709849</ref> <ref>PMID:9442027</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Bacillus coli migula 1895]] |
[[Category: Burley, S K]] | [[Category: Burley, S K]] | ||
[[Category: Gibney, S A]] | [[Category: Gibney, S A]] | ||
Revision as of 23:51, 9 September 2015
Crystal Structure of the Escherichia coli SbmC protein (AKA Gyrase Inhibitory Protein GyrI, AKA YeeB)
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