1wyk

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 4: Line 4:
|PDB= 1wyk |SIZE=350|CAPTION= <scene name='initialview01'>1wyk</scene>, resolution 2.0&Aring;
|PDB= 1wyk |SIZE=350|CAPTION= <scene name='initialview01'>1wyk</scene>, resolution 2.0&Aring;
|SITE=
|SITE=
-
|LIGAND= <scene name='pdbligand=FOR:FORMYL+GROUP'>FOR</scene> and <scene name='pdbligand=DIO:1,4-DIETHYLENE DIOXIDE'>DIO</scene>
+
|LIGAND= <scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=FOR:FORMYL+GROUP'>FOR</scene>
|ACTIVITY=
|ACTIVITY=
|GENE= POTENTIAL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11034 Sindbis virus])
|GENE= POTENTIAL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11034 Sindbis virus])
 +
|DOMAIN=
 +
|RELATEDENTRY=
 +
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wyk OCA], [http://www.ebi.ac.uk/pdbsum/1wyk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1wyk RCSB]</span>
}}
}}
Line 25: Line 28:
[[Category: Lee, S.]]
[[Category: Lee, S.]]
[[Category: Rossmann, M G.]]
[[Category: Rossmann, M G.]]
-
[[Category: DIO]]
 
-
[[Category: FOR]]
 
[[Category: alphavirus]]
[[Category: alphavirus]]
[[Category: capsid]]
[[Category: capsid]]
Line 35: Line 36:
[[Category: virus]]
[[Category: virus]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:03:06 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:42:39 2008''

Revision as of 21:42, 30 March 2008

Image:1wyk.jpg


PDB ID 1wyk

Drag the structure with the mouse to rotate
, resolution 2.0Å
Ligands: ,
Gene: POTENTIAL (Sindbis virus)
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



SINDBIS VIRUS CAPSID PROTEIN (114-264)


Overview

Alphavirus budding from the plasma membrane is initiated by the specific interaction of the nucleocapsid with the cytoplasmic domain of the glycoprotein E2. It was proposed (Lee et al., Structure 4:531-541, 1996) that binding of the capsid protein residues 108 to 110 (the "N-terminal arm" residues) to a hydrophobic pocket on the surface of the neighboring capsid protein in the crystal structure mimics the binding of the E2 C-terminal residues into this pocket. In addition, structural comparisons of wild-type and mutant Sindbis virus capsid protein (SCP) and Semliki Forest virus capsid protein suggested that budding is associated with a switch between two conformations of the hydrophobic pocket. To test the proposed mechanism, SCP(114-264), which is missing the N-terminal arm, was crystallized to examine the pocket conformation when the pocket is empty. However, the pocket was occupied by dioxane molecules from the crystallization solution. The pocket conformation was the same as that when it was occupied by the N-terminal arm, demonstrating that the pocket favors binding ligands of appropriate size and shape.

About this Structure

1WYK is a Single protein structure of sequence from Sindbis virus. Full crystallographic information is available from OCA.

Reference

Probing the potential glycoprotein binding site of sindbis virus capsid protein with dioxane and model building., Lee S, Kuhn RJ, Rossmann MG, Proteins. 1998 Nov 1;33(2):311-7. PMID:9779796

Page seeded by OCA on Mon Mar 31 00:42:39 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1wyk"
Personal tools