4nnm
From Proteopedia
(Difference between revisions)
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| - | + | ==Tax-Interacting Protein-1 (TIP-1) PDZ domain bound to Y-iCAL36 (YPTSII) peptide== | |
| - | + | <StructureSection load='4nnm' size='340' side='right' caption='[[4nnm]], [[Resolution|resolution]] 1.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4nnm]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NNM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NNM FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4nnl|4nnl]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nnm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nnm RCSB], [http://www.ebi.ac.uk/pdbsum/4nnm PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[Category: Amacher, J | + | == Function == |
| - | [[Category: Madden, D | + | [[http://www.uniprot.org/uniprot/TX1B3_HUMAN TX1B3_HUMAN]] May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6.<ref>PMID:10940294</ref> <ref>PMID:16855024</ref> <ref>PMID:21139582</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Amacher, J F]] | ||
| + | [[Category: Madden, D R]] | ||
| + | [[Category: Pdz]] | ||
| + | [[Category: Pdz-peptide]] | ||
| + | [[Category: Protein binding]] | ||
| + | [[Category: Tax-interacting protein-1]] | ||
| + | [[Category: Tip-1]] | ||
Revision as of 16:56, 21 January 2015
Tax-Interacting Protein-1 (TIP-1) PDZ domain bound to Y-iCAL36 (YPTSII) peptide
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