4nxo
From Proteopedia
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| - | ''' | + | ==Crystal Structure of Insulin Degrading Enzyme in complex with BDM44768== |
| - | + | <StructureSection load='4nxo' size='340' side='right' caption='[[4nxo]], [[Resolution|resolution]] 2.73Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4nxo]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NXO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NXO FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=2H7:4-FLUORO-N-({1-[(2R)-4-(HYDROXYAMINO)-1-(NAPHTHALEN-2-YL)-4-OXOBUTAN-2-YL]-1H-1,2,3-TRIAZOL-4-YL}METHYL)BENZAMIDE'>2H7</scene>, <scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Insulysin Insulysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.56 3.4.24.56] </span></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nxo OCA], [http://pdbe.org/4nxo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nxo RCSB], [http://www.ebi.ac.uk/pdbsum/4nxo PDBsum]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Insulysin]] | ||
| + | [[Category: Deprez, B]] | ||
[[Category: Deprez, R]] | [[Category: Deprez, R]] | ||
| - | [[Category: Liang, W | + | [[Category: Liang, W G]] |
[[Category: Tang, W]] | [[Category: Tang, W]] | ||
| - | [[Category: | + | [[Category: Cysteine free]] |
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
| + | [[Category: Inhibitor]] | ||
Revision as of 13:48, 7 October 2015
Crystal Structure of Insulin Degrading Enzyme in complex with BDM44768
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