1x5v
From Proteopedia
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|PDB= 1x5v |SIZE=350|CAPTION= <scene name='initialview01'>1x5v</scene> | |PDB= 1x5v |SIZE=350|CAPTION= <scene name='initialview01'>1x5v</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=HSL:HOMOSERINE+LACTONE'>HSL</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x5v OCA], [http://www.ebi.ac.uk/pdbsum/1x5v PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1x5v RCSB]</span> | ||
}} | }} | ||
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[[Category: inhibitory cystine knot]] | [[Category: inhibitory cystine knot]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:45:12 2008'' |
Revision as of 21:45, 30 March 2008
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| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
NMR Structure of PcFK1
Overview
Psalmopeotoxin I (PcFK1) is a 33-amino-acid residue peptide isolated from the venom of the tarantula Psalmopoeus cambridgei. It has been recently shown to possess strong antiplasmodial activity against the intra-erythrocyte stage of Plasmodium falciparum in vitro. Although the molecular target for PcFK1 is not yet determined, this peptide does not lyse erythrocytes, is not cytotoxic to nucleated mammalian cells, and does not inhibit neuromuscular function. We investigated the structural properties of PcFK1 to help understand the unique mechanism of action of this peptide and to enhance its utility as a lead compound for rational development of new antimalarial drugs. In this paper, we have determined the three-dimensional solution structure by (1)H two-dimensional NMR means of recombinant PcFK1, which is shown to belong to the ICK structural superfamily with structural determinants common to several neurotoxins acting as ion channels effectors.
About this Structure
1X5V is a Protein complex structure of sequences from Psalmopoeus cambridgei. Full crystallographic information is available from OCA.
Reference
Solution structure of PcFK1, a spider peptide active against Plasmodium falciparum., Pimentel C, Choi SJ, Chagot B, Guette C, Camadro JM, Darbon H, Protein Sci. 2006 Mar;15(3):628-34. Epub 2006 Feb 1. PMID:16452619
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