4pzq
From Proteopedia
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| - | ''' | + | ==Crystal Structure of CCG DNA repeats== |
| + | <StructureSection load='4pzq' size='340' side='right' caption='[[4pzq]], [[Resolution|resolution]] 2.24Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4pzq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PZQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PZQ FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pzq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pzq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pzq RCSB], [http://www.ebi.ac.uk/pdbsum/4pzq PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | CCG triplet repeats can fold into tetraplex structures, which are associated with the expansion of (CCG)n trinucleotide sequences in certain neurological diseases. These structures are stabilized by intertwining i-motifs. However, the structural basis for tetraplex i-motif formation in CCG triplet repeats remains largely unknown. We report the first crystal structure of a CCG-repeat sequence, which shows that two dT(CCG)3 A strands can associate to form a tetraplex structure with an i-motif core containing four C:C(+) pairs flanked by two G:G homopurine base pairs as a structural motif. The tetraplex core is attached to a short parallel-stranded duplex. Each hairpin itself contains a central CCG loop in which the nucleotides are flipped out and stabilized by stacking interactions. The helical twists between adjacent cytosine residues of this structure in the i-motif core have an average value of 30 degrees , which is greater than those previously reported for i-motif structures. | ||
| - | + | Structural basis for the identification of an i-motif tetraplex core with a parallel-duplex junction as a structural motif in CCG triplet repeats.,Chen YW, Jhan CR, Neidle S, Hou MH Angew Chem Int Ed Engl. 2014 Sep 26;53(40):10682-6. doi: 10.1002/anie.201405637. , Epub 2014 Aug 19. PMID:25139267<ref>PMID:25139267</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Chen, Y W]] | ||
| + | [[Category: Hou, M H]] | ||
| + | [[Category: Ccg triplet repeat]] | ||
| + | [[Category: Dna]] | ||
| + | [[Category: Hemiprotonated cc+ pair]] | ||
| + | [[Category: I-motif]] | ||
Revision as of 16:16, 7 January 2015
Crystal Structure of CCG DNA repeats
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