4q23
From Proteopedia
(Difference between revisions)
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| - | + | ==The role of threonine 201 and tyrosine 204 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates== | |
| - | + | <StructureSection load='4q23' size='340' side='right' caption='[[4q23]], [[Resolution|resolution]] 1.98Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4q23]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q23 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q23 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RIS:1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE+BIS-PHOSPHONIC+ACID'>RIS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kfa|4kfa]], [[4kpd|4kpd]], [[4kpj|4kpj]], [[4kqs|4kqs]], [[4kqu|4kqu]], [[4kq5|4kq5]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q23 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q23 RCSB], [http://www.ebi.ac.uk/pdbsum/4q23 PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[ | + | == Function == |
| - | [[ | + | [[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. |
| - | [[ | + | __TOC__ |
| - | [[ | + | </StructureSection> |
| - | [[ | + | [[Category: Barnett, B L]] |
| - | [[Category: | + | [[Category: Delft, F Von]] |
| - | [[Category: | + | [[Category: Dunford, J E]] |
| - | [[Category: | + | [[Category: Ebetino, F H]] |
| - | [[Category: | + | |
[[Category: Evdokimov, A]] | [[Category: Evdokimov, A]] | ||
| - | [[Category: Kwaasi, A | + | [[Category: Kavanagh, K L]] |
| - | [[Category: Muniz, J | + | [[Category: Kwaasi, A A]] |
| - | [[Category: | + | [[Category: Muniz, J R.C]] |
| + | [[Category: Oppermann, U]] | ||
| + | [[Category: Pilka, E S]] | ||
| + | [[Category: Russell, R G.G]] | ||
| + | [[Category: Tsoumpra, M K]] | ||
| + | [[Category: Walter, R L]] | ||
| + | [[Category: Alpha helical prenyltransferase]] | ||
| + | [[Category: Bisphosphonate]] | ||
| + | [[Category: Cholesterol synthesis]] | ||
| + | [[Category: Dimethylallyl pyrophospahte]] | ||
| + | [[Category: Isopentyl pyrophosphate]] | ||
| + | [[Category: Isoprene biosynthesis]] | ||
| + | [[Category: Isoprenoid pathway]] | ||
| + | [[Category: Lipid synthesis]] | ||
| + | [[Category: Steroid biosynthesis]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 12:13, 18 March 2015
The role of threonine 201 and tyrosine 204 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates
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Categories: Barnett, B L | Delft, F Von | Dunford, J E | Ebetino, F H | Evdokimov, A | Kavanagh, K L | Kwaasi, A A | Muniz, J R.C | Oppermann, U | Pilka, E S | Russell, R G.G | Tsoumpra, M K | Walter, R L | Alpha helical prenyltransferase | Bisphosphonate | Cholesterol synthesis | Dimethylallyl pyrophospahte | Isopentyl pyrophosphate | Isoprene biosynthesis | Isoprenoid pathway | Lipid synthesis | Steroid biosynthesis | Transferase
