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4qde

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'''Unreleased structure'''
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==Dcps in complex with covalent inhibitor==
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<StructureSection load='4qde' size='340' side='right' caption='[[4qde]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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The entry 4qde is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4qde]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QDE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QDE FirstGlance]. <br>
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Authors: Liu, S.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=30S:2-{[(2,4-DIAMINOQUINAZOLIN-5-YL)OXY]METHYL}BENZENESULFONIC+ACID'>30S</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4qdv|4qdv]], [[4qeb|4qeb]]</td></tr>
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Description: Dcps in complex with covalent inhibitor
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5'-(N(7)-methyl_5'-triphosphoguanosine)-(mRNA)_diphosphatase 5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.59 3.6.1.59] </span></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qde FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qde OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qde RCSB], [http://www.ebi.ac.uk/pdbsum/4qde PDBsum]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/DCPS_HUMAN DCPS_HUMAN]] Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP (PubMed:22985415). May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCPS to m7GMP (PubMed:14523240). Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death.<ref>PMID:12198172</ref> <ref>PMID:12871939</ref> <ref>PMID:11747811</ref> <ref>PMID:14523240</ref> <ref>PMID:15273322</ref> <ref>PMID:15383679</ref> <ref>PMID:16140270</ref> <ref>PMID:18426921</ref> <ref>PMID:22985415</ref> <ref>PMID:15769464</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Liu, S]]
[[Category: Liu, S]]
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[[Category: 3'->5' exosome-mediated mrna decay pathway]]
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[[Category: Decapping scavenger enzyme]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Mrna degradation]]
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[[Category: Residual cap structure cleavage]]

Revision as of 12:22, 13 May 2015

Dcps in complex with covalent inhibitor

4qde, resolution 2.90Å

Drag the structure with the mouse to rotate
[[Category: 3'->5' exosome-mediated mrna decay pathway]]

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