1xr5
From Proteopedia
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|PDB= 1xr5 |SIZE=350|CAPTION= <scene name='initialview01'>1xr5</scene>, resolution 2.80Å | |PDB= 1xr5 |SIZE=350|CAPTION= <scene name='initialview01'>1xr5</scene>, resolution 2.80Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=SM:SAMARIUM (III) ION'>SM</scene> | + | |LIGAND= <scene name='pdbligand=SM:SAMARIUM+(III)+ION'>SM</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span> |
| - | |GENE= P3D ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= | + | |GENE= P3D ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12131 Human rhinovirus 14]) |
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1teb|1TEB]], [[1te8|1TE8]], [[1te9|1TE9]], [[1xr6|1XR6]], [[1xr7|1XR7]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xr5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xr5 OCA], [http://www.ebi.ac.uk/pdbsum/1xr5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xr5 RCSB]</span> | ||
}} | }} | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1XR5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ | + | 1XR5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_rhinovirus_14 Human rhinovirus 14]. This structure supersedes the now removed PDB entry 1TEB. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XR5 OCA]. |
==Reference== | ==Reference== | ||
The crystal structure of the RNA-dependent RNA polymerase from human rhinovirus: a dual function target for common cold antiviral therapy., Love RA, Maegley KA, Yu X, Ferre RA, Lingardo LK, Diehl W, Parge HE, Dragovich PS, Fuhrman SA, Structure. 2004 Aug;12(8):1533-44. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15296746 15296746] | The crystal structure of the RNA-dependent RNA polymerase from human rhinovirus: a dual function target for common cold antiviral therapy., Love RA, Maegley KA, Yu X, Ferre RA, Lingardo LK, Diehl W, Parge HE, Dragovich PS, Fuhrman SA, Structure. 2004 Aug;12(8):1533-44. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15296746 15296746] | ||
| - | [[Category: Human rhinovirus | + | [[Category: Human rhinovirus 14]] |
[[Category: RNA-directed RNA polymerase]] | [[Category: RNA-directed RNA polymerase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 32: | Line 35: | ||
[[Category: Parge, H E.]] | [[Category: Parge, H E.]] | ||
[[Category: Yu, X.]] | [[Category: Yu, X.]] | ||
| - | [[Category: SM]] | ||
[[Category: rna-dependent rna polymerase]] | [[Category: rna-dependent rna polymerase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:53:29 2008'' |
Revision as of 21:53, 30 March 2008
| |||||||
| , resolution 2.80Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | P3D (Human rhinovirus 14) | ||||||
| Activity: | RNA-directed RNA polymerase, with EC number 2.7.7.48 | ||||||
| Related: | 1TEB, 1TE8, 1TE9, 1XR6, 1XR7
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of the RNA-dependent RNA Polymerase 3D from human rhinovirus serotype 14
Overview
Human rhinoviruses (HRV), the predominant members of the Picornaviridae family of positive-strand RNA viruses, are the major causative agents of the common cold. Given the lack of effective treatments for rhinoviral infections, virally encoded proteins have become attractive therapeutic targets. The HRV genome encodes an RNA-dependent RNA polymerase (RdRp) denoted 3Dpol, which is responsible for replicating the viral genome and for synthesizing a protein primer used in the replication. Here the crystal structures for three viral serotypes (1B, 14, and 16) of HRV 3Dpol have been determined. The three structures are very similar to one another, and to the closely related poliovirus (PV) 3Dpol enzyme. Because the reported PV crystal structure shows significant disorder, HRV 3Dpol provides the first complete view of a picornaviral RdRp. The folding topology of HRV 3Dpol also resembles that of RdRps from hepatitis C virus (HCV) and rabbit hemorrhagic disease virus (RHDV) despite very low sequence homology.
About this Structure
1XR5 is a Single protein structure of sequence from Human rhinovirus 14. This structure supersedes the now removed PDB entry 1TEB. Full crystallographic information is available from OCA.
Reference
The crystal structure of the RNA-dependent RNA polymerase from human rhinovirus: a dual function target for common cold antiviral therapy., Love RA, Maegley KA, Yu X, Ferre RA, Lingardo LK, Diehl W, Parge HE, Dragovich PS, Fuhrman SA, Structure. 2004 Aug;12(8):1533-44. PMID:15296746
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