This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1xuo

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 4: Line 4:
|PDB= 1xuo |SIZE=350|CAPTION= <scene name='initialview01'>1xuo</scene>, resolution 1.80&Aring;
|PDB= 1xuo |SIZE=350|CAPTION= <scene name='initialview01'>1xuo</scene>, resolution 1.80&Aring;
|SITE=
|SITE=
-
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=LA1:(2R)-2-[3-ISOBUTYL-2,5-DIOXO-4-(QUINOLIN-3-YLMETHYL)-1,4-DIAZEPAN-1-YL]-N-METHYL-3-(2-NAPHTHYL)PROPANAMIDE'>LA1</scene>
+
|LIGAND= <scene name='pdbligand=LA1:(2R)-2-[3-ISOBUTYL-2,5-DIOXO-4-(QUINOLIN-3-YLMETHYL)-1,4-DIAZEPAN-1-YL]-N-METHYL-3-(2-NAPHTHYL)PROPANAMIDE'>LA1</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
|ACTIVITY=
|ACTIVITY=
|GENE=
|GENE=
 +
|DOMAIN=
 +
|RELATEDENTRY=[[1xdd|1XDD]], [[1xdg|1XDG]]
 +
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xuo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xuo OCA], [http://www.ebi.ac.uk/pdbsum/1xuo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xuo RCSB]</span>
}}
}}
Line 32: Line 35:
[[Category: Weckbecker, G.]]
[[Category: Weckbecker, G.]]
[[Category: Welzenbach, K.]]
[[Category: Welzenbach, K.]]
-
[[Category: LA1]]
 
-
[[Category: MG]]
 
[[Category: i-domain]]
[[Category: i-domain]]
[[Category: integrin]]
[[Category: integrin]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:14:46 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:54:52 2008''

Revision as of 21:54, 30 March 2008

Image:1xuo.jpg


PDB ID 1xuo

Drag the structure with the mouse to rotate
, resolution 1.80Å
Ligands: ,
Related: 1XDD, 1XDG


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



X-ray structure of LFA-1 I-domain bound to a 1,4-diazepane-2,5-dione inhibitor at 1.8A resolution


Overview

1,4-Diazepane-2,5-diones (2) are found to be a new class of potent LFA-1 inhibitors. The synthesis, structure, and biological evaluation of these 1,4-diazepine-2,5-diones and related derivatives are described.

About this Structure

1XUO is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

1,4-Diazepane-2,5-diones as novel inhibitors of LFA-1., Wattanasin S, Kallen J, Myers S, Guo Q, Sabio M, Ehrhardt C, Albert R, Hommel U, Weckbecker G, Welzenbach K, Weitz-Schmidt G, Bioorg Med Chem Lett. 2005 Feb 15;15(4):1217-20. PMID:15686945

Page seeded by OCA on Mon Mar 31 00:54:52 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1xuo"
Personal tools