4r8i
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==High Resolution Structure of a Mirror-Image RNA Oligonucleotide Aptamer in Complex with the Chemokine CCL2== |
| - | + | <StructureSection load='4r8i' size='340' side='right' caption='[[4r8i]], [[Resolution|resolution]] 2.05Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4r8i]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R8I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R8I FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene></td></tr> | |
| - | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=0A:L-ADENOSINE-5-MONOPHOSPHATE'>0A</scene>, <scene name='pdbligand=0C:L-CYTIDINE-5-MONOPHOSPHATE'>0C</scene>, <scene name='pdbligand=0G:L-GUANOSINE-5-MONOPHOSPHATE'>0G</scene>, <scene name='pdbligand=0U:L-URIDINE-5-MONOPHOSPHATE'>0U</scene>, <scene name='pdbligand=0U1:2-METHYLSELENYL-2-DEOXY-L-URIDINE-5-MONOPHOSPHATE'>0U1</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r8i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r8i RCSB], [http://www.ebi.ac.uk/pdbsum/4r8i PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CCL2_HUMAN CCL2_HUMAN]] Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Achenbach, J]] | [[Category: Achenbach, J]] | ||
| - | [[Category: Oberthuer, D]] | ||
| - | [[Category: Maasch, C]] | ||
[[Category: Betzel, C]] | [[Category: Betzel, C]] | ||
[[Category: Buchner, K]] | [[Category: Buchner, K]] | ||
| - | [[Category: Rehders, D]] | ||
| - | [[Category: Klussmann, S]] | ||
[[Category: Falke, S]] | [[Category: Falke, S]] | ||
[[Category: Gabdulkhakov, A]] | [[Category: Gabdulkhakov, A]] | ||
| + | [[Category: Klussmann, S]] | ||
| + | [[Category: Maasch, C]] | ||
| + | [[Category: Oberthuer, D]] | ||
| + | [[Category: Rehders, D]] | ||
| + | [[Category: Aptamer spiegelmer l-oligonucleotide]] | ||
| + | [[Category: Cytokine-rna complex]] | ||
Revision as of 11:34, 30 April 2015
High Resolution Structure of a Mirror-Image RNA Oligonucleotide Aptamer in Complex with the Chemokine CCL2
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