This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4rfr

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 4rfr is ON HOLD until Paper Publication
+
==Complex structure of AlkB/rhein==
-
 
+
<StructureSection load='4rfr' size='340' side='right' caption='[[4rfr]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-
Authors: Li, Q., Huang, Y., Li, J.F., Yang, C.-G.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[4rfr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RFR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RFR FirstGlance]. <br>
-
Description: Complex structure of AlkB/rhein
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=RHN:4,5-DIHYDROXY-9,10-DIOXO-9,10-DIHYDROANTHRACENE-2-CARBOXYLIC+ACID'>RHN</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3t4h|3t4h]]</td></tr>
-
[[Category: Li, J.F]]
+
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_oxidative_demethylase DNA oxidative demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.11.33 1.14.11.33] </span></td></tr>
-
[[Category: Yang, C.-G]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rfr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rfr OCA], [http://pdbe.org/4rfr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rfr RCSB], [http://www.ebi.ac.uk/pdbsum/4rfr PDBsum]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/ALKB_ECOLI ALKB_ECOLI]] Dioxygenase that repairs alkylated DNA and RNA containing 3-methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing ethenoadenine, and no detectable activity towards 1-methylguanine or 3-methylthymine. Accepts double-stranded and single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. Provides extensive resistance to alkylating agents such as MMS and DMS (SN2 agents), but not to MMNG and MNU (SN1 agents).<ref>PMID:12226668</ref> <ref>PMID:12594517</ref> <ref>PMID:16482161</ref> <ref>PMID:19706517</ref> <ref>PMID:21068844</ref> <ref>PMID:20084272</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: DNA oxidative demethylase]]
[[Category: Huang, Y]]
[[Category: Huang, Y]]
 +
[[Category: Li, J F]]
[[Category: Li, Q]]
[[Category: Li, Q]]
 +
[[Category: Yang, C G]]
 +
[[Category: Alkb family]]
 +
[[Category: Demethylase]]
 +
[[Category: Demethylation]]
 +
[[Category: Jellyroll fold]]
 +
[[Category: Nucleic acid binding]]
 +
[[Category: Nucleus]]
 +
[[Category: Oxidoreductase-inhibitor complex]]
 +
[[Category: Protein-inhibitor complex]]

Revision as of 04:01, 12 May 2016

Complex structure of AlkB/rhein

4rfr, resolution 1.50Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4rfr"
Personal tools