1y8j
From Proteopedia
(Difference between revisions)
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|PDB= 1y8j |SIZE=350|CAPTION= <scene name='initialview01'>1y8j</scene>, resolution 2.25Å | |PDB= 1y8j |SIZE=350|CAPTION= <scene name='initialview01'>1y8j</scene>, resolution 2.25Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=STS:2-[(1S)-1-BENZYL-2-SULFANYLETHYL]-1H-IMIDAZO[4,5-C]PYRIDIN-5-IUM'>STS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Neprilysin Neprilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.11 3.4.24.11] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Neprilysin Neprilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.11 3.4.24.11] </span> |
|GENE= MME, EPN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= MME, EPN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1r1j|1R1J]], [[1r1i|1R1I]], [[1r1h|1R1H]], [[1dmt|1DMT]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y8j OCA], [http://www.ebi.ac.uk/pdbsum/1y8j PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1y8j RCSB]</span> | ||
}} | }} | ||
'''Crystal Structure of human NEP complexed with an imidazo[4,5-c]pyridine inhibitor''' | '''Crystal Structure of human NEP complexed with an imidazo[4,5-c]pyridine inhibitor''' | ||
| - | |||
| - | ==Disease== | ||
| - | Known diseases associated with this structure: Membranous glomerulonephritis, antenatal OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120520 120520]], Neutral endopeptidase deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120520 120520]], Schizophrenia, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=607265 607265]] | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Sahli, S.]] | [[Category: Sahli, S.]] | ||
[[Category: Schweizer, W B.]] | [[Category: Schweizer, W B.]] | ||
| - | [[Category: ACT]] | ||
| - | [[Category: NAG]] | ||
| - | [[Category: STS]] | ||
| - | [[Category: ZN]] | ||
[[Category: lt1_6]] | [[Category: lt1_6]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:00:10 2008'' |
Revision as of 22:00, 30 March 2008
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| , resolution 2.25Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , | ||||||
| Gene: | MME, EPN (Homo sapiens) | ||||||
| Activity: | Neprilysin, with EC number 3.4.24.11 | ||||||
| Related: | 1R1J, 1R1I, 1R1H, 1DMT
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of human NEP complexed with an imidazo[4,5-c]pyridine inhibitor
About this Structure
1Y8J is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Page seeded by OCA on Mon Mar 31 01:00:10 2008
Categories: Homo sapiens | Neprilysin | Single protein | Aebi, J D. | Blum-Kaelin, D. | Bohm, H J. | Dale, G E. | Diederich, F. | Frank, B. | Oefner, C. | Sahli, S. | Schweizer, W B. | Lt1 6
