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4rsy

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'''Unreleased structure'''
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==Crystal structures of the Human leukotriene A4 Hydrolase complex with a potential inhibitor H7==
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<StructureSection load='4rsy' size='340' side='right' caption='[[4rsy]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
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The entry 4rsy is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4rsy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RSY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RSY FirstGlance]. <br>
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Authors: Ouyang, P., Lu, W., Cui, K., Huang, J.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=B3N:4-(DIMETHYLAMINO)-N-[7-(HYDROXYAMINO)-7-OXOHEPTYL]BENZAMIDE'>B3N</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4r7l|4r7l]]</td></tr>
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Description: Crystal structures of the Human leukotriene A4 Hydrolase complex with a potential inhibitor H7
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukotriene-A(4)_hydrolase Leukotriene-A(4) hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.2.6 3.3.2.6] </span></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rsy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rsy OCA], [http://pdbe.org/4rsy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rsy RCSB], [http://www.ebi.ac.uk/pdbsum/4rsy PDBsum]</span></td></tr>
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[[Category: Ouyang, P]]
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</table>
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[[Category: Lu, W]]
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== Function ==
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[[http://www.uniprot.org/uniprot/LKHA4_HUMAN LKHA4_HUMAN]] Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.<ref>PMID:1897988</ref> <ref>PMID:1975494</ref> <ref>PMID:2244921</ref> <ref>PMID:12207002</ref> <ref>PMID:11917124</ref> <ref>PMID:15078870</ref> <ref>PMID:18804029</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Cui, K]]
[[Category: Cui, K]]
[[Category: Huang, J]]
[[Category: Huang, J]]
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[[Category: Lu, W]]
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[[Category: Ouyang, P]]
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[[Category: Human leukotriene a4 hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Lta4hs']]

Revision as of 16:14, 2 December 2015

Crystal structures of the Human leukotriene A4 Hydrolase complex with a potential inhibitor H7

4rsy, resolution 1.93Å

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