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4tkk

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'''Unreleased structure'''
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==Sulfolobus solfataricus HJC mutants==
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<StructureSection load='4tkk' size='340' side='right' caption='[[4tkk]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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The entry 4tkk is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4tkk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TKK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TKK FirstGlance]. <br>
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Authors: Bond, C.S.
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4tkd|4tkd]]</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Crossover_junction_endodeoxyribonuclease Crossover junction endodeoxyribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.22.4 3.1.22.4] </span></td></tr>
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Description: Sulfolobus solfataricus HJC mutants
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tkk RCSB], [http://www.ebi.ac.uk/pdbsum/4tkk PDBsum]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Bond, C.S]]
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== Function ==
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[[http://www.uniprot.org/uniprot/HJC_SULSO HJC_SULSO]] A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination; may have some degree of sequence preference in a mobile junction. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products. Can cleave all 4 strands 3 bases 3' of the junction center. Cleaves both mobile and immobile junctions. Modifies the structure of the 4-way DNA junction, a model Holliday junction structure. The protein forms multiple complexes with 4-way DNA, suggesting more than 1 homodimer can bind to each junction.<ref>PMID:10701121</ref> <ref>PMID:10736227</ref> <ref>PMID:10940317</ref> <ref>PMID:11709558</ref> <ref>PMID:17011573</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Crossover junction endodeoxyribonuclease]]
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[[Category: Bond, C S]]
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[[Category: Hydrolase]]

Revision as of 14:47, 12 August 2015

Sulfolobus solfataricus HJC mutants

4tkk, resolution 2.40Å

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