4tvq

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'''Unreleased structure'''
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==CCM3 in complex with CCM2 LD-like motif==
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<StructureSection load='4tvq' size='340' side='right' caption='[[4tvq]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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The entry 4tvq is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4tvq]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TVQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TVQ FirstGlance]. <br>
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Authors: Li, X., Zhang, R., Fisher, O.S., Boggon, T.J.
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3l8i|3l8i]], [[3l8j|3l8j]], [[3rqe|3rqe]], [[3rqf|3rqf]], [[3rqg|3rqg]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tvq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tvq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tvq RCSB], [http://www.ebi.ac.uk/pdbsum/4tvq PDBsum]</span></td></tr>
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Description:
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</table>
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[[Category: Unreleased Structures]]
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== Disease ==
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[[Category: Fisher, O.S]]
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[[http://www.uniprot.org/uniprot/PDC10_HUMAN PDC10_HUMAN]] Hereditary cerebral cavernous malformation. Defects in PDCD10 are the cause of cerebral cavernous malformations type 3 (CCM3) [MIM:[http://omim.org/entry/603285 603285]]. Cerebral cavernous malformations (CCMs) are congenital vascular anomalies of the central nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. CCMs have an incidence of 0.1%-0.5% in the general population and usually present clinically during the 3rd to 5th decade of life. The lesions are characterized by grossly enlarged blood vessels consisting of a single layer of endothelium and without any intervening neural tissue, ranging in diameter from a few millimeters to several centimeters.<ref>PMID:15543491</ref> [[http://www.uniprot.org/uniprot/CCM2_HUMAN CCM2_HUMAN]] Hereditary cerebral cavernous malformation. The disease is caused by mutations affecting the gene represented in this entry.
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[[Category: Boggon, T.J]]
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== Function ==
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[[http://www.uniprot.org/uniprot/PDC10_HUMAN PDC10_HUMAN]] Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and MST4 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity).<ref>PMID:15543491</ref> <ref>PMID:17360971</ref> <ref>PMID:20332113</ref> [[http://www.uniprot.org/uniprot/CCM2_HUMAN CCM2_HUMAN]] Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity).
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Boggon, T J]]
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[[Category: Fisher, O S]]
[[Category: Li, X]]
[[Category: Li, X]]
[[Category: Zhang, R]]
[[Category: Zhang, R]]
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[[Category: Fat-homology domain]]
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[[Category: Protein binding]]

Revision as of 14:11, 26 March 2015

CCM3 in complex with CCM2 LD-like motif

4tvq, resolution 2.80Å

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