4u7i
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Structure of the complex of Spartin MIT and IST1 MIM== |
| - | + | <StructureSection load='4u7i' size='340' side='right' caption='[[4u7i]], [[Resolution|resolution]] 1.79Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4u7i]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U7I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U7I FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4u7e|4u7e]], [[4u7y|4u7y]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u7i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u7i RCSB], [http://www.ebi.ac.uk/pdbsum/4u7i PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[ | + | == Disease == |
| - | [[Category: Guo, E | + | [[http://www.uniprot.org/uniprot/SPG20_HUMAN SPG20_HUMAN]] Defects in SPG20 are the cause of spastic paraplegia autosomal recessive type 20 (SPG20) [MIM:[http://omim.org/entry/275900 275900]]; also known as Troyer syndrome (TRS). Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG20 is characterized by dysarthria, distal amyotrophy, mild developmental delay and short stature.<ref>PMID:12134148</ref> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SPG20_HUMAN SPG20_HUMAN]] May be implicated in endosomal trafficking, or microtubule dynamics, or both.<ref>PMID:12676568</ref> [[http://www.uniprot.org/uniprot/IST1_HUMAN IST1_HUMAN]] Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells.<ref>PMID:19129479</ref> <ref>PMID:19129480</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Guo, E Z]] | ||
[[Category: Xu, Z]] | [[Category: Xu, Z]] | ||
| + | [[Category: Complex]] | ||
| + | [[Category: Mim3]] | ||
| + | [[Category: Protein transport]] | ||
Revision as of 12:02, 12 February 2015
Structure of the complex of Spartin MIT and IST1 MIM
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Categories: Guo, E Z | Xu, Z | Complex | Mim3 | Protein transport
