1yo8

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|PDB= 1yo8 |SIZE=350|CAPTION= <scene name='initialview01'>1yo8</scene>, resolution 2.60&Aring;
|PDB= 1yo8 |SIZE=350|CAPTION= <scene name='initialview01'>1yo8</scene>, resolution 2.60&Aring;
|SITE=
|SITE=
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> and <scene name='pdbligand=CA:CALCIUM ION'>CA</scene>
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
|ACTIVITY=
|ACTIVITY=
|GENE= THBS2, TSP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
|GENE= THBS2, TSP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
 +
|DOMAIN=
 +
|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yo8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yo8 OCA], [http://www.ebi.ac.uk/pdbsum/1yo8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1yo8 RCSB]</span>
}}
}}
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[[Category: Misenheimer, T M.]]
[[Category: Misenheimer, T M.]]
[[Category: Mosher, D F.]]
[[Category: Mosher, D F.]]
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[[Category: CA]]
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[[Category: ca(2+)-binding domain]]
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[[Category: NAG]]
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[[Category: disulfide]]
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[[Category: egf; ca(2+)-binding domains; lectin domain; disulfide]]
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[[Category: egf]]
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[[Category: lectin domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:25:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:15:27 2008''

Revision as of 22:15, 30 March 2008

Image:1yo8.gif


PDB ID 1yo8

Drag the structure with the mouse to rotate
, resolution 2.60Å
Ligands: , , ,
Gene: THBS2, TSP2 (Homo sapiens)
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Strucuture of the C-terminal domain of human thrombospondin-2


Overview

Thrombospondins (THBSs) are secreted glycoproteins that have key roles in interactions between cells and the extracellular matrix. Here, we describe the 2.6-A-resolution crystal structure of the glycosylated signature domain of human THBS2, which includes three epidermal growth factor-like modules, 13 aspartate-rich repeats and a lectin-like module. These elements interact extensively to form three structural regions termed the stalk, wire and globe. The THBS2 signature domain is stabilized by these interactions and by a network of 30 bound Ca(2+) ions and 18 disulfide bonds. The structure suggests how genetic alterations of THBSs result in disease.

About this Structure

1YO8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the calcium-rich signature domain of human thrombospondin-2., Carlson CB, Bernstein DA, Annis DS, Misenheimer TM, Hannah BL, Mosher DF, Keck JL, Nat Struct Mol Biol. 2005 Oct;12(10):910-4. Epub 2005 Sep 25. PMID:16186819

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