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1yq6

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|PDB= 1yq6 |SIZE=350|CAPTION= <scene name='initialview01'>1yq6</scene>, resolution 2.4&Aring;
|PDB= 1yq6 |SIZE=350|CAPTION= <scene name='initialview01'>1yq6</scene>, resolution 2.4&Aring;
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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|RELATEDENTRY=[[1yq5|1YQ5]], [[1yq8|1YQ8]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yq6 OCA], [http://www.ebi.ac.uk/pdbsum/1yq6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1yq6 RCSB]</span>
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[[Category: beta-spiral]]
[[Category: beta-spiral]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:17:34 2008''

Revision as of 22:17, 30 March 2008

Image:1yq6.gif


PDB ID 1yq6

Drag the structure with the mouse to rotate
, resolution 2.4Å
Ligands:
Related: 1YQ5, 1YQ8


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



PRD1 vertex protein P5


Overview

Comparisons of bacteriophage PRD1 and adenovirus protein structures and virion architectures have been instrumental in unraveling an evolutionary relationship and have led to a proposal of a phylogeny-based virus classification. The structure of the PRD1 spike protein P5 provides further insight into the evolution of viral proteins. The crystallized P5 fragment comprises two structural domains: a globular knob and a fibrous shaft. The head folds into a ten-stranded jelly roll beta barrel, which is structurally related to the tumor necrosis factor (TNF) and the PRD1 coat protein domains. The shaft domain is a structural counterpart to the adenovirus spike shaft. The structural relationships between PRD1, TNF, and adenovirus proteins suggest that the vertex proteins may have originated from an ancestral TNF-like jelly roll coat protein via a combination of gene duplication and deletion.

About this Structure

1YQ6 is a Single protein structure of sequence from Enterobacteria phage prd1. Full crystallographic information is available from OCA.

Reference

The structure of the bacteriophage PRD1 spike sheds light on the evolution of viral capsid architecture., Merckel MC, Huiskonen JT, Bamford DH, Goldman A, Tuma R, Mol Cell. 2005 Apr 15;18(2):161-70. PMID:15837420

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